Metabolic syndrome in adults with a history of juvenile arthritis

Figures & data

Table 1 Comparison of JA and no arthritis groups

Characteristics	Arthritis dx≤16 years (n=232)	No arthritis (n=1,028)	p-value, arthritis dx≤16 years vs no arthritis
Current age, years	47.7	43.7	0.001
Race, %
Caucasian	59	40	0.001
AA	22	21
Hispanic	14	27
Others	5	12
Gender (female), %	59	47	0.01
Weight, kg	86.4	81.5	0.04
Height, cm	168.9	169.6	0.4
Waist/height ratio	0.6	0.5	0.001
BMI, kg/m^2	30.2	28.2	0.006
Diabetes, %	16	6	0.002
Central obesity, waist circumference ≥102 cm (male) and ≥88 cm (female), %	69	54	0.001
Hypertension (≥130/85 mmHg), %	48	24	<0.001
Low HDL (<40 mg/dL, male and <50 mg/dL, female), %	34	27	0.05
High TG (≥150 mg/dL), %	34	26	0.08
High fasting glucose (≥110 mg/dL), %	39	19	0.001
Central obesity, OR (95% CI)	1.9 (1.4–2.6)		0.001
Hypertension, OR (95% CI)	3.1 (2.3–4.2)		0.001
Low HDL, OR (95% CI)	1.3 (0.9–1.8)		0.05
Elevated TG, OR (95% CI)	1.5 (0.9–2.4)		0.08
High fasting glucose, OR (95% CI)	2.8 (1.8–4.4)		0.001

Abbreviations: AA, African American; BMI, body mass index; dx, diagnosed; JA, juvenile arthritis; HDL, high-density lipoprotein; TG, triglyceride.

Figure 1 Prevalence of metabolic syndrome by age and diagnosis.

Notes: There was no significant difference between no arthritis and JA groups. The JA cohort had a younger age of presentation of metabolic syndrome compared to the RA cohort.
Abbreviations: JA, juvenile arthritis; RA, rheumatoid arthritis.

Table 2 Comparison of JA and RA groups

Characteristics	Arthritis dx≤16 years (n=232)	RA (n=1,105)	p-value, arthritis dx≤16 years vs RA
Current age, years	47.7	58.3	0.001
Race, %
Caucasian	59	41	0.001
AA	22	31
Hispanic	14	23
Others	5	5
Gender (female), %	59	61	0.7
Weight, kg	86.4	84.2	0.2
Height, cm	168.9	164.9	0.005
Waist/height ratio	0.6	0.6	0.4
BMI, kg/m^2	30.2	30.7	0.6
Central obesity, waist circumference ≥102 cm (male) and ≥88 cm (female), %	69	73	0.2
Hypertension (≥130/85 mmHg), %	48	56	0.01
Diabetes, %	16	22	0.01
Low HDL (<40 mg/dL, male and <50 mg/dL, female), %	34	33	0.8
High TG (≥150 mg/dL), %	34	30	0.4
High fasting glucose (≥110 mg/dL)	39	37	0.8
Central obesity, OR (95% CI)	0.8 (0.6–1.1)		0.2
Hypertension, OR (95% CI)	0.7 (0.5–0.9)		0.004
Low HDL, OR (95% CI)	1.1 (0.8–1.4)		0.8
Elevated TG, OR (95% CI)	1.2 (0.8–1.9)		0.4
High fasting glucose, OR (95% CI)	1.1 (0.7–1.6)		0.8

Abbreviations: JA, juvenile arthritis; RA, rheumatoid arthritis; AA, African American; BMI, body mass index; dx, diagnosed; HDL, high-density lipoprotein; TG, triglyceride.

Table 3 Odds of metabolic syndrome in JA and RA groups compared to the no arthritis group

Odds ratio	Arthritis dx≤16 years vs no arthritis		RA vs no arthritis
	Logistic regression, 95% CI	p-value	Logistic regression, 95% CI	p-value
Not adjusted	6.2 (3.1–12.6)	0.001	7.7 (5.1–11.8)	0.001
Adjusted for age, gender, and race	5.2 (2.3–11.9)	0.001	3.2 (1.9–5.2)	0.001

Abbreviations: JA, juvenile arthritis; RA, rheumatoid arthritis.