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Clinical Ophthalmology Volume 12, 2018 - Issue
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Original Research

Age-related changes in the peripheral retinal nerve fiber layer thickness

Gözde Hondur1 Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USA;2 Department of Ophthalmology, Ulucanlar Training and Research Hospital, Ankara, Turkey
,
Emre Göktaş1 Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
,
Lama Al-Aswad1 Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
&
Gülgün Tezel1 Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USACorrespondence[email protected]
Pages 401-409 | Published online: 26 Feb 2018

Figures & data

Figure 1 Retinal images were acquired using the swept-source Deep Range Imaging-OCT (DRI-OCT-1, Topcon, Tokyo, Japan).

Note: Montaging the routine wide-angle OCT image with the nasal peripheral OCT image (acquired with a contralateral gaze) yielded the composite image with a larger field, including up to 10 mm nasal and 8 mm temporal to the optic disc, and 3 mm superior and inferior to the optic disc.
Abbreviation: OCT, optical coherence tomography.
Figure 1 Retinal images were acquired using the swept-source Deep Range Imaging-OCT (DRI-OCT-1, Topcon, Tokyo, Japan).

Figure 2 The Deep Range Imaging-OCT segmentation software (Topcon, Tokyo, Japan) was used to identify the limits of the retinal nerve fiber layer as the area expanding from the internal limiting membrane to the inner boundary of the retinal ganglion cell layer.

Abbreviation: OCT, optical coherence tomography.
Figure 2 The Deep Range Imaging-OCT segmentation software (Topcon, Tokyo, Japan) was used to identify the limits of the retinal nerve fiber layer as the area expanding from the internal limiting membrane to the inner boundary of the retinal ganglion cell layer.

Figure 3 The representative composite images obtained from different age groups containing the retinal nerve fiber layer thickness data: (A) Group 1, (B) Group 2, and (C) Group 3.

Figure 3 The representative composite images obtained from different age groups containing the retinal nerve fiber layer thickness data: (A) Group 1, (B) Group 2, and (C) Group 3.

Figure 4 The peripheral RNFL thickness in different age groups.

Abbreviation: RNFL, retinal nerve fiber layer.
Figure 4 The peripheral RNFL thickness in different age groups.

Table 1 The peripheral RNFL thickness

Figure 5 The peripheral-to-peripapillary RNFL thickness ratio in different age groups.

Abbreviation: RNFL, retinal nerve fiber layer.
Figure 5 The peripheral-to-peripapillary RNFL thickness ratio in different age groups.

Table 2 The peripheral-to-peripapillary RNFL thickness ratio

Figure 6 Scatterplots of the relationship between the peripheral RNFL thickness and age.

Notes: Linear regression analysis detected a negative correlation between the peripheral RNFL thickness and age (R=0.549, P<0.001; and R=0.612, P<0.001 for nasal and temporal sides, respectively) and the peripheral-to-peripapillary RNFL thickness ratio obtained for nasal (R=0.542; P<0.001) and temporal sides (R=0.362; P=0.02).
Abbreviation: RNFL, retinal nerve fiber layer.
Figure 6 Scatterplots of the relationship between the peripheral RNFL thickness and age.

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