Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function

Figures & data

Table 1 Scaling Used to Define Groups with and without Minimal Macular Changes

Group 0-A (N = 15)	Group 0-B (N = 19)
Best VA 20/25 or better AND no macular changes observed	Best VA 20/25 or better AND minimal macular changes such as mottling, pigment changes or small drusen (<63 µm observed)

Table 2 Mean ± SD of Visual Function Tests for 0-A and 0-B Groups

Tests	Group 0-A (N = 15)	Group 0-B (N = 19)
ETDRS Distance VA Regular (LogMAR)	0.0 ± 0.11	0.08 ± 0.12
ETDRS Distance VA 2.0 (LogMAR)	0.24 ± 0.15	0.29 ± 0.14
Pell-Robson CS (log)	1.75 ± 0.29	1.78 ± 0.17
MN Read (wpm)	214 ± 47.4	210 ± 64.7
MN Read Reading Acuity (LogMAR)	0.15 ± 0.18	0.07 ± 0.09
VCF Threshold	0.47 ± 0.25	0.43 ± 0.22
High-Contrast High-Luminance (HCHL) Tablet Reading (wpm)	176 ± 66.4	183 ± 32.3
LowLuminance Tablet Reading (wpm)	137 ± 71.8	151 ± 39.4
LowContrast Tablet Reading (wpm)	57 ± 42.6	61 ± 41.5
Crowded Tablet Reading (wpm)	182 ± 70.0	170 ± 46.7
Pepper Tablet Reading (wpm)	93 ± 39.4	97 ± 22.0
Vanishing Optotypes Tablet Reading (wpm)	159 ± 70.3	174 ± 43.9

Notes: Groups 0-A vs 0-B: p > 0.05 for all comparisons, with and without adjustment for ETDRS VA.

Figure 1 Examples of fundus photos from two study eyes graded as 0-A (left; no minimal macular changes) and 0-B (right; with minimal macular changes). The black circle indicates the region in the macula where fundus retinal changes were observed.

Figure 2 Images from same eyes as shown in Figure 1 under high magnification (A, B) and under gray scale (C, D) to better visualize the minimal macular changes seen in subject ID 042. The black circle indicates the region in the macula where fundus retinal changes were observed.