Clinical presentation, treatment, and prognosis of periocular and orbital amyloidosis in a university-based referral center

Figures & data

Figure 1 Amyloid deposition appearing as an amorphous, eosinophilic extracellular substance in the stroma of a subepithelial area of the eyelid.

Figure 2 Congo red stain demonstrating orange-red deposits of amyloid.

Table 1 Patients’ data and details of periocular and orbital amyloidosis

Patient	Age	Sex	Eye	Symptoms and signs	Sites	Treatment	Outcome
1	47	F	LE	Mass, irritation, ptosis	Eyelid, conj	Sx debulking, levator resection	Stable
2	79	M	LE	Mass at punctum, epiphora	Punctum	Canaliculotomy	Stable
3	46	F	LE	Mass, irritation	Eyelid Lacrimal gland	Sx excision	Progression at conj.
4	20	F	LE	Mass, irritation, bloody tears	Eyelid	Sx excision	Stable
5	31	F	LE	Irritation, eye pain	Conj	Incisional biopsy	Progression
6	15	F	BE	Mass	Eyelids	Sx excision	Stable

Abbreviations: BE, both eyes; conj, conjunctiva; F, female; Lacrimal gl, Lacrimal gland; LE, left eye; M, male; Sx debulk, Surgical debulking; Sx excision, Surgical excision.

Figure 3 A 31-year-old woman who presented with a petechial hemorrhage above a conjunctival mass in the inferior area.

Table 2 Clinical presentation of periocular and orbital amyloidosis

Clinical presentation	Number of patients (%)
Mass lesion	5 (83.3%)
Eye irritation	4 (66.7%)
Bloody tears	1 (16.7%)
Eye pain	1 (16.7%)
Epiphora	1 (16.7%)
Blepharoptosis	1 (16.7%)