Impact of tumor volume doubling time on post-metastatic survival in bone or soft-tissue sarcoma patients treated with metastasectomy and/or radiofrequency ablation of the lung

Figures & data

Table 1 Patients background

Characteristic	Total
Age
Mean (years)	56
Range (years)	12–88
Sex
Male	27
Female	21
Maximum diameter of metastases
Mean (mm)	11
Range (mm)	3–35
Number of metastases
Mean	4
Range	1–17
Tumor volume doubling time
Mean (days)	69
Median (days)	35
Range (days)	10–506
Treatment for lung metastases
Metastasectomy alone	10
RFA alone	21
Both	17
Chemotherapy for lung metastases
Yes	25
No	23

Abbreviation: RFA, radiofrequency ablation.

Figure 1 Kaplan–Meier curve of post-metastatic survival in bone or soft-tissue sarcoma patients (n=48) treated with metastasectomy and/or radiofrequency ablation of the lung.

Table 2 Univariate analysis for survival

Variables	HR	95% CI	P-value
Age (years)	1.011	0.991–1.031	0.28
Gender
&emsp,Female	0.899	0.440–1.839	0.77
Metastasis at presentation
&emsp,No	1.079	0.412–2.822	0.88
Size (mm)	1.044	1.002–1.088	0.04
Number	1.125	1.031–1.227	0.008
Curability
&emsp,Complete	0.291	0.142–0.597	0.0008
DFI (months)	0.98	0.962–0.999	0.04
TVDT (days)	0.966	0.948–0.985	0.0004

Abbreviations: HR, hazard risk; CI, confidence interval; DFI, disease-free interval; TVDT, tumor volume doubling time.

Table 3 Multivariate analysis for survival

Variables	HR	95% CI	P-value
Size (mm)	1.037	0.98–1.097	0.21
Number	0.997	0.869–1.144	0.97
Curability
Complete	0.165	0.058–0.466	0.0007
DFI (months)	1.003	0.987–1.020	0.68
TVDT (days)	0.949	0.925–0.972	<0.0001

Abbreviations: HR, hazard risk; CI, confidence interval; DFI, disease-free interval; TVDT, tumor volume doubling time.

Table 4 Predictive factors which related with curability

Variables	Resectability		P-value
	Complete (n=30)	Incomplete (n=18)
Age (years)
Mean	52	63	0.08
Gender
Male	16	11	0.6
Female	14	7
Metastasis at presentation
No	26	14	0.42
Yes	4	4
Size (mm)
Mean	10.3	12.1	0.28
Number	2.2	6.3	<0.0001
DFI (months)	26.8	14.5	0.12
TVDT (days)
Mean	85.1	42.2	0.62

Abbreviations: DFI, disease-free interval; TVDT, tumor volume doubling time.

Figure 2 Kaplan–Meier curves of post-metastatic survival in bone or soft-tissue sarcoma patients (n=48) with (A) complete treatment and a tumor volume doubling time (TVDT) of >30 days, (B) incomplete treatment and a TVDT of >30 days, (C) complete treatment and a TVDT of ≤30 days, and (D) incomplete treatment and a TVDT of ≤30 days.