Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis

Figures & data

Figure 1 Flow chart of study selection.

Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CML, chronic myeloid leukemia; HWE, Hardy–Weinberg equilibrium; SNP, single nucleotide polymorphism.

Table 1 Study characteristics

Study	Ethnicity	Cases	SNP	Number of cases	Number of controls	PHWE in controls
Agha et al^Citation29	Caucasian	ALL	T3801C, C4887A	186	200	0.0577
Aydin-Sayitoglu et al^Citation30	Caucasian	ALL	T3801C	249	140	0.3057
		AML	T3801C	249	140	0.3057
Bolufer et al^Citation31	Caucasian	ALL	T3801C	443	454	0.151
		AML	T3801C	443	454	0.151
Bonaventure et al^Citation32	Caucasian	ALL	T3801C	493	549	0.2309
		AML	T3801C	493	549	0.2309
Krajinovic et al^Citation27	Caucasian	ALL	T3801C	177	304	0.3941
			C4887A			0.1355
Ouerhani et al^Citation33	Caucasian	ALL	T3801C	100	106	0.5731
Swinney et al^Citation12	Caucasian	ALL	T3801C, A2455G	258	646	0.1272
Yamaguti et al^Citation13	Caucasian	ALL	T3801C	99	99	0.1701
			A2455G			0.9485
Selvin^Citation49	Caucasian	ALL	A2455G	175	175	0.9347
Gao et al^Citation34	Asian	ALL	T3801C	78	112	0.1723
			A2455G			0.1357
Joseph et al^Citation35	Asian	ALL	T3801C	118	118	0.5939
			A2455G			0.141
Lee et al^Citation36	Asian	ALL	T3801C	164	164	0.4015
			A2455G			0.4514
Suneetha et al^Citation37	Asian	ALL	T3801C	92	150	0.806
Balta et al^Citation38	Mixed	ALL	T3801C	144	185	0.0907
		AML	T3801C	144	185	0.0907
Canalle et al^Citation39	Mixed	ALL	T3801C	113	221	0.083
Clavel et al^Citation40	Mixed	ALL	T3801C	219	105	0.1861
		AML	T3801C	219	105	0.1861
Gallegos-Arreola et al^Citation41	Mixed	ALL	T3801C	210	228	0.7728
Razmkhah et al^Citation43	Mixed	ALL	A2455G	85	94	0.4353
		AML	A2455G	85	94	0.9543
		CML	A2455G	85	94	0.9543
Gallegos-Arreola et al^Citation48	Mixed	ALL	A2455G	136	136	0.315
D’Alo et al^Citation44	Caucasian	AML	T3801C	193	273	0.1604
			A2455G			0.4279
			C4887A			0.7257
Jiang et al^Citation45	Asian	AML	T3801C	98	120	0.1062
Kim et al^Citation46	Asian	AML	T3801C	415	1,700	0.6805
			A2455G			0.0688
Majumdar et al^Citation21	Asian	AML	T3801C	110	126	0.8415
Yamaguti et al^Citation47	Mixed	AML	T3801C	133	133	0.1381
			A2455G			0.3451
Al-Achkar et al^Citation42	Caucasian	CML	A2455G	126	172	0.3253
Taspinar et al^Citation22	Caucasian	CML	A2455G	107	135	0.5889

Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CML, chronic myeloid leukemia; P_HWE, probability of adherence to the Hardy–Weinberg equilibrium; SNP, single nucleotide polymorphism.

Table 2 ORs and heterogeneity results for CYP1A1 meta-analysis

SNP	Cancer	Ethnicity	n	Genetic model	I^2	Contrast model	P, ORs (95% CIs)
T3801C	ALL	Caucasian	8	Recessive	26%	Fixed effects	0.28, 1.31 (0.81, 2.12)
				Dominant	61%	Random effects	0.10, 1.30 (0.95, 1.79)
				Allele contrast	32%	Fixed effects	0.05, 1.18 (1.00, 1.39)
		Asian	4	Recessive	63%	Random effects	0.73, 1.14 (0.54, 2.39)
				Dominant	68%	Random effects	0.06, 1.64 (0.98, 2.73)
				Allele contrast	80%	Random effects	0.19, 1.35 (0.86, 2.14)
		Mix	4	Recessive	76%	Random effects	0.21, 2.68 (0.57, 12.62)
				Dominant	82%	Random effects	0.32, 1.34 (0.75, 2.39)
				Allele contrast	92%	Random effects	0.34, 1.42 (0.69, 2.91)
A2455G	ALL	Caucasian	4	Recessive	0%	Fixed effects	0.002, 2.23 (1.36, 3.68)
				Dominant	39%	Fixed effects	0.12, 1.22 (0.95, 1.58)
				Allele contrast	41%	Fixed effects	0.010, 1.31 (1.07, 1.61)
		Asian	3	Recessive	11%	Fixed effects	0.14, 1.57 (0.87, 2.83)
				Dominant	72%	Random effects	0.29, 1.40 (0.76, 2.59)
				Allele contrast	0%	Fixed effects	0.89, 1.02 (0.80, 1.29)
		Mix	1	Recessive		Fixed effects
				Dominant		Fixed effects	0.94, 1.03 (0.45, 2.34)
				Allele contrast		Fixed effects	0.94, 1.03 (0.47, 2.26)
C4887A	ALL	Caucasian	1	Recessive		Fixed effects	0.61, 1.67 (0.23, 11.99)
				Dominant		Fixed effects	0.14, 0.57 (0.27, 1.21)
				Allele contrast		Fixed effects	0.22, 0.65 (0.33, 1.30)
T3801C	AML	Caucasian	4	Recessive	0%	Fixed effects	0.26, 1.74 (0.66, 4.55)
				Dominant	47%	Fixed effects	0.16, 0.82 (0.62, 1.08)
				Allele contrast	59%	Random effects	0.63, 0.90 (0.59, 1.37)
		Asian	3	Recessive	0%	Fixed effects	0.60, 0.93 (0.71, 1.22)
				Dominant	0%	Fixed effects	0.03, 1.26 (1.02, 1.55)
				Allele contrast	0%	Fixed effects	0.23, 1.09 (0.95, 1.26)
		Mix	3	Recessive	0%	Fixed effects	0.72, 1.19 (0.46, 3.05)
				Dominant	74%	Random effects	0.65, 1.24 (0.48, 3.22)
				Allele contrast	72%	Random effects	0.81, 1.11 (0.48, 2.55)
A2455G	AML	Caucasian	1	Recessive
				Dominant		Fixed effects	0.47, 0.78 (0.39, 1.53)
				Allele contrast		Fixed effects	0.48, 0.78 (0.40, 1.53)
		Asian	1	Recessive		Fixed effects	0.39, 0.79 (0.47, 1.35)
				Dominant		Fixed effects	0.42, 1.09 (0.88, 1.36)
				Allele contrast		Fixed effects	0.72, 1.03 (0.87, 1.23)
		Mix	2	Recessive	0%	Fixed effects	0.50, 1.64 (0.39, 6.92)
				Dominant	0%	Fixed effects	0.0009, 1.96 (1.32, 2.90)
				Allele contrast	0%	Fixed effects	0.002, 1.72 (1.22, 2.43)
C4887A	AML	Caucasian	1	Recessive		Fixed effects	0.39, 2.85 (0.26, 31.63)
				Dominant		Fixed effects	0.005, 2.16 (1.27, 3.69)
				Allele contrast		Fixed effects	0.004, 2.08 (1.26, 3.44)
A2455G	CML	Caucasian	2	Recessive	17%	Fixed effects	0.004, 19.61 (2.62, 146.76)
				Dominant	69%	Random effects	0.0010, 3.93 (1.74, 8.87)
				Allele contrast	1%	Fixed effects	P,0.00001, 3.92 (2.61, 5.90)
		Mix	1	Recessive		Fixed effects	0.89, 0.80 (0.03, 20.00)
				Dominant		Random effects	0.79, 0.88 (0.34, 2.29)
				Allele contrast		Fixed effects	0.70, 0.84 (0.34, 2.07)

Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CI, confidence interval; CML, chronic myeloid leukemia; OR, odds ratio; SNP, single nucleotide polymorphism.

Figure 2 Meta-analysis of the association between CYP1A1 T3801C gene polymorphism and ALL risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.

Abbreviations: ALL, acute lymphoblastic leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; SE, standard error.

Figure 3 Meta-analysis of the association between CYP1A1 A2455G gene polymorphism and ALL risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.

Abbreviations: CML, chronic myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; ALL, acute lymphoblastic leukemia.

Figure 4 Meta-analysis of the association between CYP1A1 T3801C gene polymorphism and AML risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.

Abbreviations: AML, acute myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; SE, standard error.

Figure 5 Meta-analysis of the association between CYP1A1 A2455G gene polymorphism and CML risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.

Abbreviations: ALL, acute lymphoblastic leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; SE, standard error; CML, chronic myeloid leukemia.

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