ABO histo-blood group and risk of respiratory atopy in children: a review of published evidence

Figures & data

Table 1 Histo-blood group systems and risk of respiratory atopy: summary of studies in adults

Study	Type of study (study population)	Histo-blood group systems	Atopy risk (OR, 95% CI)	Study strengths	Study limitations
Kauffmann et al^Citation18	Cross-sectional study (228 adult coal miners)	Blood group O/Lewis negative	Asthma risk (NA)a	Assessed the three histo-blood groups	No controls used in the study
Falsarella et al^Citation20	Cross-sectional case-control study (168 adults >18 years, 168 matchedcontrols)	Blood group O	Allergic rhinitis risk (2.8, 1.385–5.616)b	Controls matched for age and sex	Small sample size Only ABO histo-blood group was assessed
Alo et al^Citation22	Cross-sectional case-control study (200 adult asthmatics, 100 adult controls)	Blood group A	Asthma risk (NA)a	Assessed ABO and Rhesus phenotypes	Age range of subjects not stated Controls not age or sex matched Small sample size Odds ratio not estimated
Khetsuriani and Gamkrelidze^Citation39	Cross-sectional case-control study (293 subjects with respiratory atopy, 83 with intrinsic asthma and 215 controls)	O(I), MN, O(I)MN, MNFya(−), O(I)Fya(−) and O(I)MNFya(−) phenotypes B(III), M and B(III)M phenotypes O(I) and MN phenotypes	Respiratory atopic disease riska Severe atopic bronchial asthma riska Mild-to-moderate atopic bronchial asthma riska	Assessed ABO, Rh, MNSs, P, Duffy, and Kell histo-blood systems	Controls not matched

Note:

a Significant association;

b significant association in males only.

Abbreviations: OR, odds ratio; NA, not available.

Table 2 Histo-blood group systems and risk of respiratory atopy: summary of studies in children

Study	Type of study (study population)	Histo-blood group systems	Atopy risk (OR, 95% CI)	Study strengths	Study limitations
Chen et al^Citation17	Cross-sectional case-control study (135 asthmatic children, 161 age-matched controls)	Blood group O/secretor phenotypes Blood group O/Lewis (a−b−)	Asthma risk (2.7, 1.126–6.033)a Asthma risk (3.6, 1.080–11.963)a	Studied combined effect of three histo-blood groups Study population randomly selected	Small sample size Controls matched for age but not sex
Ronchetti et al^Citation21	Cross-sectional case-control study (165 asthmatic children, 362 infants)	A, B or AB/non-secretor	Asthma risk for <1 year olds (2.6, 0.88–7.30), 1–5 years (2.1, 0.86–4.91)a,b	Assessed both ABO/secretor phenotypes	Controls not matched for age or sex
Bijanzadeh et al^Citation23	Cross-sectional case-control study (200 asthmatic children and adults, 2000 controls)	Blood groups O, B, A and AB (in that order)	Asthma risk (NA)c	Controls were used	Controls not matched Odds ratio not estimated
De la Vega AR et al^Citation19	Cross-sectional case–control study (115 children, 1001 controls)	Blood groups Aand O Gene frequencies for A (p) and O (r) different for subjects and controls	Asthma risk (NA)a	Assessed ABO and Rhesus phenotypes ABO gene frequencies were calculated	Controls not matched

Note:

a Significant association;

b significant association in males only;

c no significant association.

Abbreviations: OR, odds ratio; NA, not available.

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