Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw

Figures & data

Table 1 Comparison of hydrogen and hydrogen-rich saline

	Hydrogen	Hydrogen-rich saline
Explosiveness	High	Low
Convenience of application	Requires a sealed chamber or mask in hospital	Easy to use anywhere
Portability	Poor	Good
Administration route	Inhalation	Oral ingestion, peritoneal injection, intravenous injection
Safety	Poor	Good
Limit of concentration	High (because of its explosiveness)	Low
Effectiveness	Yes	Yes

Figure 1 An experiment is designed for this hypothesis.

Abbreviations: ORNJ, osteoradionecrosis of the jaw; BMSCs, bone marrow mesenchymal stem cells; CT, computed tomography; MFB, myofibroblast.