Eligibility for alirocumab or evolocumab treatment in 1090 hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol ≥70 mg/dL despite maximal-tolerated LDL-cholesterol-lowering therapy

Figures & data

Figure 1 HeFH and atherosclerotic CVD in 1090 patients with LDLC ≥70 mg/dL after ≥2 months maximal-tolerated cholesterol-lowering therapy.

Notes: One hundred forty patients with HeFH and/or CVD (13% of the referred cohort) eligible for PCSK9 inhibitor therapy by US Food and Drug Administration and commercial insurance guidelines by virtue of LDLC on maximal-tolerated therapy >100 (dosage was MTDLLT, which included zero dose statin for those with statin intolerance).
Abbreviations: CVD, cardiovascular disease; HeFH, heterozygous familial hypercholesterolemia; LDLC, low-density lipoprotein cholesterol; MTDLLT, maximal-tolerated dose of standard-of-care LDL cholesterol-lowering therapy; PCSK9, proprotein convertase subtilisin/kexin type 9.

Table 1 LDLC in 353 patients with HeFH and/or CVD at entry and after 2 months on maximal-tolerated LDLC-lowering therapy

Group	Mean±SD	25th percentile	50th percentile	75th percentile	n (%) of LDLC >100 mg/dL
HeFH and/or CVD, n=353
Initial LDLC (mg/dL)	137±53	94	127	171	246 (70%)
Last follow-up LDLC	105±36	79	93	121	140 (40%)
Lp(a) (mg/dL), n=202	40±48	7	21	56	128 (63%) <35 mg/dL; 74 (37%) ≥35
HeFH and/or CVD, and follow-up LDLC ≤100, n=213
Initial LDLC (mg/dL)	126±50	87	113	159	134 (63%)
Last follow-up LDLC	83±9	75	82	89	0 (0%)
Lp(a) (mg/dL), n=118	39±49	9	19	52	75 (64%) <35 mg/dL; 43 (36%) ≥35
HeFH and/or CVD, and follow-up LDLC >100, n=140
Initial LDLC (mg/dL)	154±54	112	147	193	112 (80%)
Last follow-up LDLC	138±37	112	132	154	140 (100%)
Lp(a) (mg/dL), n=84	40±48	7	23	59	53 (63%) <35 mg/dL; 31 (37%) ≥35

Notes: Lp(a) was available for 202 patients.

Abbreviations: CVD, cardiovascular events; HeFH, heterozygous familial hypercholesterolemi; LDLC, low-density lipoprotein cholesterol; Lp(a), lipoprotein (a).