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Review

Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence

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Pages 463-472 | Published online: 17 Dec 2009

Figures & data

Figure 1 LS mean IIEF-EF scores in patients with ED and diabetes, stratified by type of antidiabetic medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

Figure 6 LS mean SEP3 success rates in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

*P < 0.0001 for vardenafil vs placebo, **P = 0.3536 for comparison of lipid-lowering medication subgroups.

Abbreviations: ED, erectile dysfunction; LOCF, last observation carried forward; LS, least squares; SEP, sexual encounter profile question.
Figure 6 LS mean SEP3 success rates in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.3536 for comparison of lipid-lowering medication subgroups.

*P < 0.0001 for vardenafil vs placebo, **P = 0.1972 for comparison of antidiabetic medication subgroups.

Abbreviations: ED, erectile dysfunction; IIEF-EF, erectile function domain of the International Index of Erectile Function; LOCF, last observation carried forward; LS, least squares.

Figure 6 LS mean SEP3 success rates in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.3536 for comparison of lipid-lowering medication subgroups.
Figure 1 LS mean IIEF-EF scores in patients with ED and diabetes, stratified by type of antidiabetic medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell. Figure 6 LS mean SEP3 success rates in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.3536 for comparison of lipid-lowering medication subgroups.Abbreviations: ED, erectile dysfunction; LOCF, last observation carried forward; LS, least squares; SEP, sexual encounter profile question.Display full size*P < 0.0001 for vardenafil vs placebo, **P = 0.1972 for comparison of antidiabetic medication subgroups.Abbreviations: ED, erectile dysfunction; IIEF-EF, erectile function domain of the International Index of Erectile Function; LOCF, last observation carried forward; LS, least squares.

Figure 6 LS mean SEP3 success rates in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

*P < 0.0001 for vardenafil vs placebo, **P = 0.3536 for comparison of lipid-lowering medication subgroups.

Abbreviations: ED, erectile dysfunction; LOCF, last observation carried forward; LS, least squares; SEP, sexual encounter profile question.
Figure 6 LS mean SEP3 success rates in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.3536 for comparison of lipid-lowering medication subgroups.

Figure 2 LS mean SEP3 success rates in patients with ED and diabetes, stratified by type of antidiabetic medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

*P < 0.0001 for vardenafil vs placebo, **P = 0.0986 for comparison of antidiabetic medication subgroups.

Abbreviations: ED, erectile dysfunction; LOCF, last observation carried forward; LS, least squares; SEP, sexual encounter profile question.
Figure 2 LS mean SEP3 success rates in patients with ED and diabetes, stratified by type of antidiabetic medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.0986 for comparison of antidiabetic medication subgroups.

Figure 3 LS mean IIEF-EF scores in patients with ED and hypertension, stratified by type of antihypertensive medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

*P < 0.0001 for vardenafil vs placebo, **P = 0.1651 for comparison of antihypertensive medication subgroups.

Abbreviations: ACE, angiotensin-converting enzyme; ARB, angiotensin II receptor antagonists; B, beta blockers; C, calcium channel antagonists; D, thiazide or thiazide-like diuretics; ED, erectile dysfunction; IIEF-EF, erectile function domain of the International Index of Erectile Function; LOCF, last observation carried forward; LS, least squares.
Figure 3 LS mean IIEF-EF scores in patients with ED and hypertension, stratified by type of antihypertensive medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.1651 for comparison of antihypertensive medication subgroups.

Figure 4 LS mean SEP3 success rates in patients with ED and hypertension, stratified by type of antihypertensive medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

*P < 0.0001 for vardenafil vs placebo, **P = 0.7957 for comparison of antihypertensive medication subgroups.

Abbreviations: ACE, angiotensin-converting enzyme; ARB, angiotensin II receptor antagonists; B, beta blockers; C, calcium channel antagonists; D, thiazide or thiazide-like diuretics; ED, erectile dysfunction; LOCF, last observation carried forward; LS, least squares; SEP, sexual encounter profile question.
Figure 4 LS mean SEP3 success rates in patients with ED and hypertension, stratified by type of antihypertensive medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.7957 for comparison of antihypertensive medication subgroups.

Figure 5 LS mean IIEF-EF scores in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.

*P < 0.0001 for vardenafil vs placebo, **P = 0.9169 for comparison of lipid-lowering medication subgroups.

Abbreviations: ED, erectile dysfunction; IIEF-EF, erectile function domain of the International Index of Erectile Function; LOCF, last observation carried forward; LS, least squares.
Figure 5 LS mean IIEF-EF scores in patients with ED and dyslipidemia, stratified by type of lipid-lowering medication, at baseline and following 12 weeks of treatment with vardenafil or placebo. Reproduced with permission from Eardley I, Lee Jay C, Shabsigh R, et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med. 2009.Citation66 In press. Copyright © 2009 Wiley-Blackwell.*P < 0.0001 for vardenafil vs placebo, **P = 0.9169 for comparison of lipid-lowering medication subgroups.