Perceived nervousness and moodiness associated with increased CVD but not cancer morbidity in pre- and postmenopausal women. Observations from the Population Study of Women in Gothenburg, Sweden

Figures & data

Table 1 Prevalence of nervousness/moodiness (NM1 and NM2) among the women in 1968–1969 examination, 32-year mortality (total and for women who reported NM1 in 1968–1969) as well as morbidity 1968/1980–2001

						Mortality 1968–2001						Morbidity
Year of birth	Participants	Prevalence of NM1		NM2		Dead 1968–2001		Reported NM1		No reported NM1		CVD 1980–2001		Cancer 1968–2001
	n	n	%	n	%	n	%	n	%	n	%	n	%	n	%
1908	81	33	41	12	15	70	86	28	85	42	88	28	35	26	33
1914	180	77	43	44	24	111	62	54	70*	57	55	56	32	51	29
1918	398	155	39	81	20	159	40	73	47*	86	35	54	14	111	29
1922	431	183	42	84	20	126	59	54	30	72	29	55	13	102	25
1930	372	152	41	75	20	58	16	27	18	31	14	12	3	71	20
Total	1462	600	41	296	20	524	36	236	39*	288	33	205	15	361	26

Note: *p < 0.05.

Abbreviation: CVD, cardiovascular disease.

Table 2 Association between nervousness/moodiness (NM1 and NM2) and risk of death in a 32-year perspective; all women divided into two groups, controlled for age and all risk factors, respectively. Total mortality, CVD mortality, and cancer mortality are presented

	n	HR	CI	p
Total mortality
NM1 + age	1347	1.18	0.98–1.42	0.07
Multivariable	1347	1.12	0.94–1.35	0.21
NM2 + age	1347	1.39	1.13–1.72	0.002
Multivariable	1347	1.28	1.03–1.58	0.02
CVD mortality
NM1 + age	1347	1.38	1.04–1.83	0.03
Multivariable	1347	1.33	1.00–1.77	0.05
NM2 + age	1347	1.58	1.14–2.18	0.005
Multivariable	1347	1.47	1.06–2.04	0.02
Cancer mortality
NM1 + age	1347	0.86	0.61–1.20	0.37
Multivariable	1347	0.82	0.58–1.14	0.24
NM2 + age	1347	0.90	0.59–1.38	0.63
Multivariable	1347	0.83	0.54–1.27	0.39

Abbreviations: CVD, cardiovascular disease; HR, hazards ratio; CI, confidence interval.

Table 3 Association between nervousness/moodiness (NM1 and NM2) and CVD and cancer morbidity, respectively, in a 32-year perspective; all women presented as well as divided in groups for premenopausal and postmenopausal in 1968–1969. Calculations controlled for age as well as multivariable controlled presented

CVD morbidity	n	HR	CI	p
All women
NM1 + age	1344	1.32	1.12–1.56	0.001
Multivariable	1344	1.29	1.09–1.52	0.003
NM2+ age	1344	1.32	1.08–1.60	0.006
Multivariable	1344	1.27	1.04–1.54	0.02
Women premenopausal in 1968–1969
NM1+ age	828	1.28	1.02–1.61	0.03
Multivariable	828	1.28	1.02–1.62	0.03
NM2 + age	828	1.46	1.10–1.93	0.009
Multivariable	828	1.44	1.08–1.91	0.01
Women postmenopausal in 1968–1969
NM1 + age	449	1.32	1.03–1.70	0.03
Multivariable	449	1.21	0.94–1.56	0.13
NM2 + age	449	1.10	0.83–1.47	0.49
Multivariable	449	1.02	0.76–1.36	0.89
Cancer morbidity
NM1 + age	1345	1.02	0.82–1.28	0.86
Multivariable	1345	1.00	0.80–1.25	0.98
NM2 + age	1345	1.09	0.83–1.42	0.55
Multivariable	1345	1.05	0.80–1.38	0.72
Women premenopausal in 1968–1969
NM1 + age	828	1.18	0.87–1.58	0.28
Multivariable	828	1.14	0.84–1.53	0.40
NM2 + age	828	1.13	0.78–1.66	0.50
Multivariable	828	1.08	0.74–1.57	0.69
Women postmenopausal in 1968–1969
NM1 + age	450	0.90	0.62–1.30	0.57
Multivariable	450	0.92	0.63–1.34	0.65
NM2 + age	450	1.02	0.66–1.58	0.93
Multivariable	450	1.03	0.67–1.60	0.89

Abbreviations: HR, hazards ratio; CI, confidence interval.