Recent advances in neutralizing the IL-6 pathway in arthritis

Figures & data

Table 1 Potential role of IL-6 cytokine protein family members in arthritis

IL-6 family member	Increased in RA?	Reduced by anti-IL-6?	Reduced by inhibiting LIF-R?	References
APN	Yes	?	?	^Citation118
OSM	Yes	?	No	^Citation119, ^Citation123a
PBEF	Yes	?	?	^Citation118
LIF	Yes	?	Yes	^Citation120, ^Citation123a

a Inhibiting LIF-R did not alter the biological activity of IL-6.

Abbreviations: APN, adiponectin; OSM, oncostatin M; PBEF, pre-B-cell colony enhancing factor/visfatin; LIF, leukemia inhibitory factor.

RhoYHSolusJSokkaTAdipocytokines are associated with radiographic joint damage in rheumatoid arthritisArthritis Rheum20096071906191419565493

 PubMed Web of Science ®Google Scholar

BarnesTCMootsRJTargeting oncostatin M in the treatment of rheumatoid arthritisTakPPProgress in Inflammation Research New Therapeutic Targets in Rheumatoid ArthritisBaselBirkhäuser2009181191

 Google Scholar

MetzSNaethGHeinrichPCMϋller-NewenGNovel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptorsJ Biol Chem2008283105985599518174171

 PubMed Web of Science ®Google Scholar

EnomotoHSaitoSYabeHToyamaYTomatuTThe levels of leukemia inhibitory factor in synovial tissue of patients with rheumatoid arthritis; inflammation and other proinflammatory cytokinesMod Rheumatol200313212112824387170

 PubMedGoogle Scholar