Effects of the vasodilating beta-blocker nebivolol on smoking-induced endothelial dysfunction in young healthy volunteers

Figures & data

Figure 1 Study protocol.

Table 1 Summary of forearm blood flow changes between Days 1, 7, and 14, before and after smoking 1 cigarette

	Change in blood flow (mL/min)
	Change	N	Mean	SD
Before smoking	Day 14–Day 1	20	–0.09	1.01
	Day 7–Day 7	21	–0.33	0.80
	Day 14–Day 1	20	0.25	0.75
After smoking	Day 14–Day 7	20	–0.07	1.22
	Day 7–Day 1	21	0.08	1.23
	Day 14–Day 7	20	–0.18	1.39

Table 2 Summary of forearm blood flow before and after smoking 1 cigarette on Days 1, 7, and 14

		Blood flow (mL/min)
		N	Mean	SD
Day 1	Before smoking	21	1.42	S0.90
	After smoking	21	1.45	1.17
	Change		0.03	0.63
Day 7	Before smoking	21	1.09	0.53
	After smoking	21	1.53	1.23
	Change		0.44*	0.91
Day 14	Before smoking	20	1.37	0.74
	After smoking	20	1.41	0.82
	Change		0.03	0.29

* p= 0.00656.

Table 3 Laboratory data efficacy on Days 1 and 14

		N	Mean	SD
Antithrombin II (%)	Day 1	20	94.62	11.49
	Day 14	19	98.78	12.88
	Change		3.83	16.33
Fibrinogen (G/L)	Day 1	20	2.79	0.49
	Day 14	19	2.57	0.40
	Change		–0.25	0.52
hs-CRP (mg/L)	Day 1	19	2.05	1.96
	Day 14	19	1.14	1.51
	Change		–1.04	2.58

Abbreviation: hs-CRP, high-sensitive-C-reactive protein.