Severe bone marrow suppression and hepatic dysfunction caused by piperacillin/tazobactam

Abstract

Piperacillin/tazobactam (TZP) is a commonly prescribed antibiotic. Here, we report a patient who developed agranulocytosis, thrombocytopenia, and severe hepatic dysfunction on day 17 while receiving TZP treatment for an intracranial infection. Bone marrow suppression and hepatic dysfunction are serious adverse effects that should be kept in mind when using long-term TZP.

Keywords::

• Piperacillin/tazobactam
• bone marrow suppression
• agranulocytosis
• thrombocytopenia
• hepatic dysfunction
• adverse effect

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.