Five-year progression-free survival in 577 patients operated on with laparoscopic radical prostatectomy for localized prostate cancer

Abstract

Objective. Laparoscopic radical prostatectomy (LRP) was introduced in the Department of Urology, Oslo University Hospital, in 2002. The aim of this study was to report mid-term oncology results and survival data. Material and methods. From February 2002 to November 2007, 582 consecutive patients with localized prostate cancer underwent LRP. Data were collected prospectively into a database. Results. Mean and median follow-up after LRP was 30.3 months (± 15.5) and 36.0 months (range 3–72). Five patients (1%) were lost during follow-up. Two patients died of prostate cancer during the study period and 10 patients died of other causes. The overall positive surgical margin (PSM) rate was 29% and decreased to 13% for the last 100 patients. The overall PSA progression-free survival (PFS) was 85% at 3 years and 73% at 5 years. Gleason score in the tumour specimen, pT stage and surgical margins were statistical significant independent predictors of biochemical PFS. Conclusion. These oncology results and 5-year PFS data after LRP are in line with other reports.

Key Words::

• laparoscopic radical prostatectomy
• progression-free survival
• prostate cancer

Acknowledgement

The study was sponsored by a grant from the Norwegian Cancer Association. The authors acknowledge statistician Lien My Diep at the Research Department, Oslo University Hospital, Aker, for her help in the preparation of the manuscript.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.