Delayed Hypersensitivity Reaction to Restylane^® SubQ

Abstract

Purpose: To report on 4 patients who developed delayed hypersensitivity reactions to Restylane^® SubQ and their management. To our knowledge, no cases of delayed hypersensitivity to Restylane^® SubQ have been previously reported.

Methods: A retrospective case series of 4 patients who were treated with preperiosteal Restylane^® SubQ to their cheeks, for facial volume augmentation. All 4 patients were subsequently referred with delayed hypersensitivity reactions over a 4-month period.

Results: The hypersensitivity reactions occurred from 1 week to 4 months’ post-cheek augmentation using Restylane^® SubQ. All patients had previously (and some since) been treated with other non-animal stabilized hyaluronic acid (NASHA) products without adverse effect. Hyaluronidase led to fast and effective resolution in all cases, although 2 of the patients required repeat treatment.

Conclusion: Hyaluronidase was effective at treating the inflammatory reaction and breaking up the retained Restylane^® SubQ in all patients. Although Restylane^® SubQ should be avoided in these patients, in our experience this does not preclude them from using other similar NASHA products.

KEYWORDS::

• Delayed
• ypersensitivity
• SubQ
• hyaluronidase

Declaration of interest: The authors report no conflicts of interest. The authors are responsible for the content and writing of the paper.