Tumour perfusion assessment during regional hyperthermia treatment: Comparison of temperature probe measurement with H₂¹⁵O-PET perfusion

Figures & data

Figure 1. 3D CT scan with superimposed fused perfusion-weighted PET image shows the ROI used to estimated positions of the rectal catheter (A), vaginal catheter (B), and tumour (C).

Figure 2. Comparison of the differences (post, pre) of the perfusion values determined by using the temperature probe and those determined using H₂¹⁵O-PET at the position of the temperature probe. ▵: rectal perfusion difference patients with cancer of the uterine cervix, □: rectal perfusion difference in patients with rectal cancer, ◯: cervical perfusion in patients with cancer of the uterine cervix.

Table I.  Perfusion was assessed using the temperature probe, PET using a VOI at the location of the temperature probe, and PET using a VOI at the tumour. Mean perfusion values measured at the beginning of heating/before RHT (pre) and end of heating/after RHT (post) are provided. Additionally, the difference (diff.) between both measurements and the average (mean) of both measurements are provided. Cervical perfusion was determined in patients with cervical cancer and rectal perfusion in patients with rectal cancer and cervical cancer.

		Temp. probe	PET probe^†	PET tumour^‡
		Mean ± SD*	Mean ± SD	Mean ± SD
Tissue		mL/(min 100 g)	mL/(min 100 cm^3)	mL/(min 100 cm^3)
Cervical in cervical cancer	pre	14.0 ± 8.7	87.3 ± 53.1	60.3 ± 41.9
	post	13.6 ± 9.2	71.2 ± 48.2	58.1 ± 46.2
	diff.	−1.0 ± 3.6	−16.2 ± 28.3	−2.2 ± 7.4
	mean	13.8 ± 8.7	79.3 ± 42.7	59.2 ± 42.7
Rectal in rectal cancer	pre	9.5 ± 4.2	22.1 ± 24.7	37.4 ± 17.9
	post	13.7 ± 5.6	28.0 ± 24.9	32.8 ± 19.6
	diff.	4.2 ± 6.2	5.9 ± 11.2	−2.4 ± 5.3
	mean	11.6 ± 5.2	29.4 ± 23.8	35.1 ± 17.9
Rectal in cervical cancer	pre	13.1 ± 10.1	26.9 ± 20.1
	post	12.2 ± 4.5	22.3 ± 17.5
	diff.	−0.9 ± 7.7	−4.6 ± 18.1
	mean	12.6 ± 7.5	24.6 ± 18.4
All	pre	12.6 ± 8.3	49.5 ± 46.7	50.4 ± 35.6
	post	13.1 ± 6.6	43.6 ± 39.4	48.6 ± 39.3
	diff.	0.5 ± 6.1	−0.2 ± 34.7	−1.8 ± 7.0
	mean	12.8 ± 7.4	46.6 ± 42.8	49.5 ± 36.7

*Standard deviation.

^†Perfusion at the position of the temperature probe.

^‡Mean tumour perfusion.

Figure 3. Comparison of the perfusion values determined by using the temperature probe and those determined using H₂¹⁵O-PET at the position of the temperature probe. The filled line represents the result of linear regression and the broken line the fit error as standard deviation. Filled symbols (▴, •,

indicate mean PET perfusion prior to hyperthermia versus temperature probe perfusion at beginning of heating. Open symbols (▵, □, ◯) indicate mean PET perfusion after hyperthermia versus temperature probe perfusion at end of heating. The symbols ▵, ▴ indicate rectal perfusion patients with cancer of the uterine cervix; □, ▪ rectal perfusion in patients with rectal cancer ◯, • cervical perfusion in patients with cancer of the uterine cervix.

Figure 4. CT image with fused perfusion-weighted PET image shows the ROI used for the position of the catheter in the bladder.