Ultrasound-guided high intensity focused ultrasound treatment for extra-abdominal desmoid tumours: Preliminary results

Figures & data

Table I.  Patient and tumour characteristics.

Patient	Age/Sex	Treatment before HIFU ablation	Maximum tumour size (cm)	Number of treated tumours	Tumour location	Ablation ratio (%)	Follow up duration (months)	HIFU retreatment
1	15/M	2 resections	9.5	3	right leg	78	55	once
2	12/M	4 resections	11.2	4	right leg and buttock	85	53	twice
3	57/M	1 resection	5.9	2	right chest wall	89	49	no
4	19/M	1resection	7.5	2	left chest wall	93	36	no
5	33/F	2 resections	10.4	3	left leg and groin	82	34	no
6	28/F	no	8.5	1	abdominal wall	100	19	no
7	5/M	2 resections	12.8	4	left leg and buttock	86	18	no
8	7/F	3 resections	9.1	3	left leg and buttock	92	18	no
9	10/M	1 resection	7.0	2	right buttock	90	9	no
10	32/M	no	10.0	1	right back	100	8	no

Patient 1 and patient 2 received pre-scheduled two HIFU ablation sessions separated by one month. Patient 1 received one HIFU ablation session one year later for enlarged residual tumours, patient 2 received two HIFU ablation sessions one and two years later for enlarged residual tumours.

Figure 1. A 7-year-old girl with multiple recurrent desmoid tumour nodules in the left leg and buttock, who received three surgical resections before HIFU ablation. Further resection was considered impossible. HIFU ablation was performed with a palliative aim. (A) Before HIFU ablation, there were multiple tumour nodules (arrows) which showed high enhancement on coronal T1-weighted contrast-enhanced MRI. (B) One month after HIFU ablation, almost all treated tumours (arrows) showed no enhancement. (C) Nine months after HIFU ablation, the treated area (arrow) showed no enhancement and shrank significantly. (D) Sixteen months after HIFU ablation, the treated area (arrow) showed no enhancement and shrank further.

Figure 2. A 28-year-old woman with an abdominal wall desmoid tumour receiving no treatment before HIFU ablation. (A) Before HIFU ablation, the tumour (arrow) showed high enhancement on transverse T1-weighted contrast-enhanced MRI. (B) Four days after HIFU ablation, the treated area (arrow) showed no contrast enhancement, the skin overlying the treated area was swollen. (C) Ten months after HIFU ablation, no contrast enhancement was observed in the treated area (arrow), which shrank significantly. (D) Eighteen months after HIFU ablation, no enhancement was observed in the treated area (arrow), which shrank further.