MicroCT image-generated tumour geometry and SAR distribution for tumour temperature elevation simulations in magnetic nanoparticle hyperthermia

Figures & data

Figure 1. Simulation domain in the COMSOL software, including a mouse body and an implanted tumour.

Figure 2. Maximum intensity projection (MIP) of a microCT scan of a tumour.

Figure 3. Approximation of a tumour geometry constructed in ProE® from 13 microCT slices.

Figure 4. Prototype of the same tumour constructed in ProE® from 30 microCT slices.

Figure 5. Greyscale microCT image slices (top panels) and the SAR distribution in the COMSOL software (bottom panels).

Table I. Physical and physiological properties of the tumour and mouse body.

	Density ρ (kg/m^3)	Heat capacity c (J/(kg °C))	Thermal conductivity k (W/(m °C))	Blood perfusion rate ω (1/s)	Metabolic heat generation rate qm (W/m^3)
Tumour	1000	3500	0.5	0.0004	29 000
Mouse body	1000	3500	0.5	0.008	450

Figure 6. Temperature contours in the tumour and the mouse body in the COMSOL simulations.

Figure 7. Steady-state temperature distributions in the three tumours.

Table II. Energy deposition rate and temperature elevations in the three tumours.

	SARmax (W/m^3)	Energy depositionrate (W)	Tmin (°C)	Tmax (°C)	Tave (°C)
Tumour 1	2 900 000	0.62	45	55	50
Tumour 2	2 900 000	0.33	42	51	47
Tumour 3	2 200 000	0.39	41	52	47