Sequential vapour ablation of adjacent segments in canine lung

Figures & data

Figure 1. In a previous study [8] FRC and body weight were measured for each animal prior to treatment. A linear regression was done through this dataset and the resultant function (FRC = 40.26 × Weight + 112.21) was used to estimate FRC of each canine prior to treatment. This FRC estimate was used in the calculation of the vapour dose.

Figure 2. The excised canine lung (right) with lung volume reduction compared to a dried lung (left) from an untreated canine of similar size.

Table 1. Clinical observations in the period following treatment 1 (P1) and the period following treatment 2 (P2).

Canine	1		2		3		4		5		6
Treatment order	LB1-distal	LB1D1	LB1D1	LB1-distal	LB1-distal	LB1D1	LB1-distal	LB1D1	LB1D1	LB1-distal	LB1D1	LB1-distal
Clinical observation	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2
Coughing	–	–	–	–	–	–	–	–	–	–	–	–
Sputum	–	–	–	–	–	–	–	–	–	–	–	–
Abnormal attitude/behaviour	–	–	–	–	–	–	–	–	–	–	–	–
Weight loss	Mod	Mod	Mild	–	–	–	–	–	Mild	–	–	–
Abnormal lung auscultation	–	–	–	–	–	–	–	–	–	–	–	–
Body condition score	–	–	2.5	2.5	–	–	–	–	–	2.5	–	–
Above normal body temperature	–	–	–	–	–	–	–	–	–	–	–	–
Abnormal arterial oxygen saturation	–	–	–	–	–	–	–	–	–	–	–	–
Respiratory distress	–	–	–	–	–	–	–	–	–	–	–	–
Pneumothorax	–	–	–	–	–	–	–	–	–	–	–	–
Death	–	–	–	–	–	–	–	–	–	–	–	–

Mod, moderate; Body condition score 1, emaciated; 3, normal; 5, obese; – not observed.

Table 2. Clinical pathology excursions from reference range.

Canine	1		2		3		4		5		6
Treatment order	LB1-distal	LB1D1	LB1D1	LB1-distal	LB1-distal	LB1D1	LB1-distal	LB1D1	LB1D1	LB1-distal	LB1D1	LB1-distal
Clinical pathology	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2
Anaemia	–	–	–	–	Mild	–	–	–	–	–	–	–
Decrease CO2	–	–	–	Mild	Mild	Mild	–	–	–	–	–	Mild
Hyperalbuminaemia	–	–	Mild	–	Mild	Mild	–	–	–	–	Mild	Mild
Hyperchloraemia	–	–	Mild	Mild	Mild	–	Mild	–	–	–	Mild	–
Hyperphosphataemia	Mild	–	–	–	Mild	–	Mild	Mild	–	–	–	–
Hyponatraemia	Mild	–	–	–	–	Mild	–	–	–	–	Mild	–
Hypoglycaemia	–	–	–	Mild	–	–	–	–	Mild	–	–	–
Hypoproteinaemia	Mild	–	–	–	–	–	Mild	–	Mild	–	–	–
Lymphocytosis	–	–	–	–	–	–	–	Mild	–	–	–	–
Neutropaenia	–	–	–	Mild	–	–	–	–	–	–	Mild	–
Thrombocytopaenia	–	–	–	–	–	–	–	Mild	–	–	–	–

Table 3. Summary of airway score, lobar volume reduction, and abnormality results from the gross pathology. (+1 dilated, 0 no change from baseline, −1 stenosed (narrowed but not fully occluded), −2 occluded).

Animal ID	LB1D1 airway score	LB1-distal airway score	Presence of volume reduction?	Abnormalities noted?
12C0166	−1	−1	Yes	No
13C0002	0	−1	Yes	No
13C0010	−1	−1	Yes	No
13C0023	−1	0	Yes	No
13C0031	−1	0	Yes	No
13C0041	−1	−2	Yes	No

Tuck SA, Lopes-Berkas V, Beam S, Anderson JC. Bronchoscopic thermal vapor ablation in a canine model of emphysema. Int J COPD 2012;7:21–31

 Google Scholar