Predictive value of indocyanine green retention rate with respect to complications of radiofrequency ablation in 878 patients with hepatocellular carcinoma

Figures & data

Table 1. Complications of 85 patients.

	n (cases)	Incidence (%)	Outcome
Bleeding	11	12.9	Cure
Bile leakage	9	10.6	Cure
Fever	26	30.6	Cure
Pleural effusion	11	12.9	Cure
Seroperitoneal effusion	14	16.5	Cure
Liver dysfunction	8	9.4	Cure
Liver abscess	6	7.1	Cure

Table 2. Clinical data of the two groups.

	Complication group (n = 85 cases)	Complication-free group (n = 793 cases)	P Values
Age (years)	55.74 ± 13.35	54.92 ± 12.02	0.553
Sex (male:female) (cases)	73:12	649:144	0.354
Alpha-fetoprotein (ug/L)	1361.16 ± 4133.98	3104.07 ± 53818.91	0.766
Haemoglobin (g/L)	11.76 ± 1.41	11.93 ± 1.47	0.324
Platelet count ( × 10^9/L)	197.31 ± 63.03	202.00 ± 61.41	0.504
Alanine aminotransferase (IU/L)	45.38 ± 41.62	48.83 ± 60.79	0.610
Aspartate aminotransferase (IU/L)	50.22 ± 63.32	46.53 ± 49.58	0.527
Total bilirubin (μmol/L)	20.26 ± 7.09	20.83 ± 11.44	0.508
Direct bilirubin (μmol/L)	8.90 ± 3.73	9.12 ± 5.80	0.736
Alkaline phosphatase (IU/L)	104.93 ± 42.68	100.53 ± 39.35	0.332
Gamma-glutamyl transpeptidase (IU/L)	71.11 ± 81.73	70.96 ± 74.69	0.986
Albumin (g/L)	39.00 ± 6.70	39.17 ± 5.92	0.806
PT (s)	12.72 ± 2.10	12.55 ± 1.69	0.319
PTINR	1.04 ± 0.09	1.05 ± 0.13	0.788
Diameter (cm)	2.98 ± 0.95	2.95 ± 0.86	0.790
ICGR15 (%)	13.44 ± 13.72	10.59 ± 11.50	0.034*
Child-Pugh (A:B) (cases)	60:25	599:194	0.316
Site
Subcapsular (cases)	72	25	<0.001*
Near porta hepatis (cases)	8	266	<0.001**
Inside liver parenchyma (cases)	5	502

ICGR15, indocyanine green retention rate at 15 min; PT, Prothrombin time; PTINR, Prothrombin time international normalised ratio.

*Compared to inside liver parenchyma, p < 0.05; **Compared to inside liver parenchyma, p < 0.05.

Table 3. Logistic regression results.

	B	SE	Wald-χ^2	P value	Exp (B)	Exp (B) 95%CI
ICGR15	0.024	0.013	3.243	0.072	1.024	0.998–1.051
Diameter	−0.083	0.204	0.166	0.683	0.920	0.616–1.373
Child-Pugh	0.241	0.429	0.317	0.574	1.273	0.549–2.952
Site			162.470	<0.001
Site (subcapsular)	6.082	0.561	117.610	<0.001	437.810	145.858–1314.134
Site (near porta hepatis)	1.207	0.587	4.231	0.040	3.344	1.059–10.566

ICGR15, indocyanine green retention rate at 15 min.

B, regression coefficient. SE, standard error.

Table 4. Comparison of ICGR15 values of patients with the same Child-Pugh grade between the two groups.

	ICGR15 values (%) Complication group	ICGR15 values (%) No complication group	P Value
Child-Pugh A	13.41 ± 14.94	10.48 ± 11.45	0.067
Child-Pugh B	13.49 ± 10.47	10.91 ± 11.69	0.295

ICGR15, indocyanine green retention rate at 15 min.

Table 5. Comparison of ICGR15 values of patients in the same tumour site between the two groups.

	ICGR15 values (%) Complication group	ICGR15 values (%) No complication group	P Value
Subcapsular	11.26 ± 12.21	13.00 ± 13.57	0.573
Near porta hepatis	9.51 ± 10.93	20.60 ± 17.41	0.116
Inside liver parenchyma	11.12 ± 11.75	8.24 ± 3.47	0.584

ICGR15, indocyanine green retention rate at 15 min.