Primary aldosteronism among newly diagnosed and untreated hypertensive patients in a Swedish primary care area

Figures & data

Figure 1. Flow diagram of patients with newly diagnosed hypertension screened with the aldosterone to renin ratio (ARR).

Table I. Clinical and biochemical variables in patients screened for PA with a raised ARR and a normal ARR.

Variables	Ratio > 65 n = 36 (IQR)	Ratio < 65 n = 164 (IQR)	p-value
Heredity (n)	11 (31%)	72 (44%)	0.14
Systolic BP (mmHg)	160 (20)	160 (20)	0.93
Diastolic BP (mmHg)	95 (10)	95 (14)	0.47
S-Na^+ (mmol/L)	141 (3)	141 (3)	0.66
S-K^+ (mmol/L)	3.8 (0.3)	4.0 (0.4)	0.002
Creatinine (umol/L)	70 (16)	72 (18)	0.27
SAC 1 (pmol/L)	354 (148)	204 (182)	< 0.0001
SAC 2 (pmol/L)	330 (136)	207 (178)	< 0.0001
PRC 1 (mIU/L)	4.0 (2.2)	12 (8.5)	< 0.0001
PRC 2 (mIU/L)	3.6 (2.8)	11.0 (8.2)	< 0.0001
Age (years)	58 (8)	60 (18)	0.29
Gender (m/f)	12/24	79/92	0.24

Table II. Clinical and biochemical variables in patients with a positive and a negative fludrocortisone suppression test (FST).

Variables	Positive fludrocortisone suppression test n = 11 (IQR)	Negative fludrocortisone suppression test n = 16 (IQR)	p-value
Heredity (n)	4 (36%)	7 (44%)	0.67
Systolic BP (mmHg)	165 (28)	160 (20)	0.44
Diastolic BP (mmHg)	100 (8)	92 (12)	0.47
S-K^+ (mmol/L)	3.7 (0.5)	3.8 (0.2)	0.32
Creatinine (umol/L)	70 (14)	76 (10)	0.13
Age (years)	46 (22)	58 (7)	0.22
Gender (m/f)	6/5	7/9	0.58

Figure 2. Box plot analysis of the value of plasma potassium (mmol/L) in patients with PA and in patients with essential hypertension, p between mean values = 0.003.

Table III. Clinical and biochemical variables in patients with PA and patients with essential hypertension.

Variables	PA n = 11 (IQR)	Essential hypertension n = 189 (IQR)	p-value
Heredity (n)	4 (57%)	79 (72%)	0.72
Systolic BP (mmHg)	165 (28)	160 (20	0.72
Diastolic BP (mmHg)	100 (8)	95 (12)	0.11
S-Na^+ (mmol/L)	143 (4)	141 (3)	0.27
S-K^+ (mmol/L)	3.7 (0.5)	4.0 (0.4)	0.003
Creatinine (umol/L)	70 (14)	72 (17)	0.25
SAC 1 (pmol/L)	327 (240)	237 (212)	< 0.005
SAC 2 (pmol/L)	356 (199)	231 (200)	< 0.003
PRC 1 (mIU/L)	4.0 (2.2)	10 (9.0)	< 0.0001
PRC 2 (mIU/L)	2.9 (2.9)	10.0 (9.6)	< 0.0001
Age (years)	46 (22)	60 (17)	0.07
Gender (m/f)	6/5	78/111	0.39