Tumour differentiation grade is associated with TNM staging and the risk of node metastasis in colorectal cancer

Figures & data

Table I. Differentiation grade definitions, distribution and demography.

		Definition	Distribution	Age	Positive nodes in stage III *	Proportion stage IV (M1) at diagnosis **
Differentiation grade		Gland formation in percent	n (%)	median (interquartile range)	mean (range)	n (%)
Well	G1	>95%	55 (4.4%)	73 (59–80)	1.6 (1–5)	3 (5.5%)
Medium	G2	>50%	914 (73.8%)	70 (61–78)	3.4 (1–20)	104 (11.4%)
Poor	G3	<50%	216 (17.4%)	71 (61–78)	5.0 (1–31)	34 (15.7%)
Undiff	G4	<5%	54 (4.3%)	66 (59–78)	3.8 (1–15)	9 (16.7%)
Total		NA	1239	71 (61–78)	3.9 (1–31)	150/1239 (12.1%)

*ANOVA, p < 0.0002

**Likelihood ratio, p < 0.001

Table II. Patient demography.

Age -median (interquartile range)	71 (61–78)
Gender -n (%)	Male 626 (50.5%) Female 613 (49.5%)
Diagnosis -n (%)	Colon 808 (65.2%) Rectum 431 (34.8%)
Emergency procedures -n (%)	154 (12.4%)
Stage distribution -n (%)	I 129 (10.4%) II 447 (36.1%) III 513 (41.4%) IV 150 (12.1%)

Figure 1. Overall TNM stage by tumour differentiation grade (p<0.0001).

Figure 2. The local tumour (T) stage (p<0.0001) and the regional lymph node (N) stage (p<0.0001) by tumour differentiation grade.

Figure 3. The prevalence of the node metastasis, N-status (NO-2) described by T-stage (1-4) and tumour differentiation grade (G1-4).