Difference in hormone receptor content in breast cancers from Vietnamese and Swedish women

Figures & data

Table I. Patient and tumor characteristic of different study populations.

Variables	Vietnamese (n = 249)	Swedish (n = 1 257)
Age (years)
Mean (SD)	47.5 (9.1)	60.7 (13.3)
Menopausal status	n (%)	n (%)
Premenopause	159 (64)	310 (25)
Postmenopause	85 (34)	864 (69)
Missing data	5 (2)	83 (6)
Tumor size (mm)
Mean (SD)	38.7 (16.3)	23.7 (14.9)
Missing data	0 (0)	16 (1)
Pathology type	n (%)	n (%)
Ductal carcinoma	217 (86)	867 (69)
Others	32 (14)	390 (31)
Carcinoma in situ component	17 (7)	21 (2)
Axillary lymph node dissection
Mean (SD)	11.0 (3.8)	9.4 (5.2)
Missing data	0 (0)	55 (4)
Lymph node involvement	n (%)	n (%)
Negative	141 (57)	692 (55)
Positive	108 (43)	508 (40)
Missing data	0 (0)	57 (5)
Clinical stage	n (%)	n (%)
I	26 (11)	655 (52)
II	175 (70)	553 (44)
III	48 (19)	49 (4)

Values are numbers and percentages in parentheses (or means and SD if specified).

Table II. Comparison of hormone receptor status between Vietnamese and Swedish patients with respect to menopausal status.

		ER				PgR
		Vietnamese n (%)	Swedish n (%)	P-value	OR* (95% CI)	Vietnamese n (%)	Swedish n (%)	P-value	OR* (95% CI)
All patients	Positive	151 (62)	800 (68)	0.060	0.76	113 (46)	793 (68)	<0.001	0.41
	Negative	93 (38)	374 (32)		(0.58–1.02)	131 (54)	381 (32)		(0.31–0.55)
Premenopause	Positive	113 (71)	181 (58)	0.007	1.75	92 (58)	226 (73)	0.001	0.51
	Negative	46 (29)	129 (42)		(1.16–2.64)	67 (42)	84 (27)		(0.34–0.76)
Postmenopause	Positive	38 (45)	619 (72)	<0.001	0.32	21 (25)	567 (66)	<0.001	0.17
	Negative	47 (55)	245 (28)		(0.20–0.50)	64 (75)	297 (34)		(0.10–0.29)

*Vietnamese patients versus Swedish patients; Odds ratio adjusted for clinical stage.

Table III. Distribution of subtypes by hormone receptor status in the two national populations studied.

Subtypes*	Vietnamese n (%)	Swedish n (%)	P-value X^2 test
ER (+) and PgR (+)	103 (41)	734 (58)
ER (−) and PgR (+)	12 (5)	116 (9)
ER (+) and PgR (−)	51 (21)	119 (10)
ER (−) and PgR (−)	83 (33)	288 (23)
Total	249 (100)	1 257 (100)	<0.001

*Estrogen receptor positive/negative (ER +/−); Progesterone receptor positive/negative (PgR +/−).

Table IV. Odds ratios and 95% confidence intervals for positivity in hormone receptor status between Vietnamese and Swedish patients with respect to age group.

Age group	ER OR* (95% CI)	PgR OR* (95% CI)
≤40	4.21 (1.95–9.10)	0.71 (0.35–1.46)
41–50	1.20 (0.73–1.99)	0.45 (0.28–0.74)
51–60	0.52 (0.31–0.87)	0.17 (0.09–0.29)
≥61	0.19 (0.07–0.49)	0.28 (0.11–0.72)

*Vietnamese patients versus Swedish patients; Odds ratio adjusted for clinical stage.

Figure 1. The trends of ER and PgR positivity in relation to age of patients.