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Letter

Bilateral macular ischemia and severe visual loss following trastuzumab therapy

, , , &
Pages 477-478 | Received 20 Dec 2010, Accepted 12 Jan 2011, Published online: 08 Feb 2011

Figures & data

Figure 1 A. Color fundus images 1 month after the initiation of trastuzumab: small hemorrhages and hard exudates were present in the macular area of both eyes. B. Early phase of the fluorescein angiography (FA) showing a significant enlargement of the foveal avascular zone. C. The late-phase of FA showed dye leakage from the perifoveal capillaries. D. Spectral-domain OCT showed bilateral cystic macular edema associated with serous retinal detachment.

Figure 1 A. Color fundus images 1 month after the initiation of trastuzumab: small hemorrhages and hard exudates were present in the macular area of both eyes. B. Early phase of the fluorescein angiography (FA) showing a significant enlargement of the foveal avascular zone. C. The late-phase of FA showed dye leakage from the perifoveal capillaries. D. Spectral-domain OCT showed bilateral cystic macular edema associated with serous retinal detachment.

Figure 2. Early phase of the fluorescein angiography in the left eye after resuming trastuzumab treatment: new areas of perifoveal capillary drop-out were observed.

Figure 2. Early phase of the fluorescein angiography in the left eye after resuming trastuzumab treatment: new areas of perifoveal capillary drop-out were observed.

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