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Acta Oncologica Volume 50, 2011 - Issue 8
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Letter

Leptomeningeal melanomatosis: Stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine

Niklas SchaeferDivision of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
,
Katja RaschDivision of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
,
Markus MoehlenbruchDepartment of Radiology, University of Bonn Medical Center, Bonn, Germany
,
Horst UrbachDepartment of Radiology, University of Bonn Medical Center, Bonn, Germany
,
Moritz StuplichDivision of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
,
Elias BlasiusDivision of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
,
Bjoern SchefflerInstitue of Reconstructive Neurobiology, University of Bonn Medical Center, Bonn, Germany
,
Ulrich HerrlingerDivision of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
&
Martin GlasDivision of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany;Institue of Reconstructive Neurobiology, University of Bonn Medical Center, Bonn, GermanyCorrespondence[email protected]
 show all
Pages 1260-1262 | Received 27 Apr 2011, Accepted 02 May 2011, Published online: 08 Jul 2011

Figures & data

Figure 1a and c. Axial T1-weighted contrast-enhanced scans (3,0T, TR 550, TE 13) after radiochemotherapy but before treatment with adjuvant TMZ and intrathecal DepoCyte showing widespread subependymal enhancement (a, arrow), parenchymal metastases of the occipital lobe (c, arrow) with perifocal edema (a, arrowhead). b and d. Corresponding images (3,0T, TR 550, TE 13) 12 months later without evidence of leptomeningeal or subependymal lesions (b, arrow) while the cerebral parenchymal metastases (d, arrow) and the perifocal edema (b, arrowhead) increased in size.

Figure 1a and c. Axial T1-weighted contrast-enhanced scans (3,0T, TR 550, TE 13) after radiochemotherapy but before treatment with adjuvant TMZ and intrathecal DepoCyte showing widespread subependymal enhancement (a, arrow), parenchymal metastases of the occipital lobe (c, arrow) with perifocal edema (a, arrowhead). b and d. Corresponding images (3,0T, TR 550, TE 13) 12 months later without evidence of leptomeningeal or subependymal lesions (b, arrow) while the cerebral parenchymal metastases (d, arrow) and the perifocal edema (b, arrowhead) increased in size.

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