Calling attention to radiation recall reactions. Simultaneous occurrence of a Recall Dermatitis after CMF application in two separate sites irradiated 10 years apart

Figures & data

Table I. Drugs reported to induce radiation recall reactions.

Substance group	Substance	Reaction
Antibiotics	Actinomycin	dermatitis
	Bleomycin	dermatitis
	Isoniazid	dermatitis
	Pyrazinamid	dermatitis
	Rifampizin	dermatitis
Anthrazyclines	Doxorubicin	dermatitis, pneumonitis, esophagitis
	Epirubicin	dermatitis
	Daunorubicin	dermatitis
	Idarubicin	vaginal necrosis
Antimetabolites	Methotrexat	dermatitis
	Fluorouracil	dermatitis
	Capecitabine	dermatitis, gastritis
	Gemcitabine	dermatitis, myositis, colitis, opticus neuronitis, brainstem radionecrosis, lymphangitis
	Thioguanin	dermatitis
	Cytarabin	supraglottitis
	Mercaptopurin	dermatitis
Alkylating agents	Cyclophosphamid	dermatitis, panniculitis, myositis
	Ifosfamid	dermatitis
Podophylinderivates	Etoposid	dermatitis
Taxanes	Docetaxel	dermatitis, mucositis
	Paclitaxel	dermatitis, colitis, pneumonitis
Vinca-alkaloids	Vinblastin	dermatitis
	Vincristin	dermatitis
	Vindesin	dermatitis
Platin compounds	Oxaliplatin	dermatitis
Other cytostatics	Hydroxyurea	erythema
Antioestrogens	Tamoxifen	dermatitis
Statines	Simvastatin	dermatitis
Interleukin	Interferon alpha 2B	dermatitis
Antibody	Trastuzumab	dermatitis

Table II. CTC Grading system (version: 2.0) for recall dermatitis according to the National Cancer Institute (NCI).

Grade 0	Grade 1	Grade 2	Grade 3	Grade 4
No event	Faint erythema or dry desquamation	Moderate to brisk erythema or a patchy moist desquamation, mostly confined to skin folds and creases; moderate edema	Confluent moist desquamation, ≥1.5 cm diameter, not confined to skin folds; pitting edema	Skin necrosis or ulceration of full thickness dermis; may include bleeding not induced by minor trauma or abrasion