Biologic targets identified from dynamic ¹⁸FDG-PET and implications for image-guided therapy

Figures & data

Figure 1. Target definition workflow: parametric images (top) produce respective threshold regions (middle), and clinical margins are applied (bottom). Perfusion is in green, metabolic rate in blue, and overlap in red.

Figure 2. The Dice's similarity coefficient (DSI) between BTV_per and BTV_met as a function of the clinical margin for each region.

Table I. Results from the dose planning given as median and range. The p-values results from of a Mann-Whitney test of the dose metrics in BTV_per and BTV_met.

Boost	DVH	PTV	BTVper	BTVmet	p-value
BTVper	D98	54.9 Gy [52.1–56.0]	62.5 Gy [59.7–64.0]	58.7 Gy [56.0–60.8]	< 0.01
	Mean	60.4 Gy [58.7–61.2]	69.3 Gy [67.1–70.2]	67.2 Gy [60.1–69.2]	< 0.01
BTVmet	D98	55.6 Gy [52.4–58.8]	58.7 Gy [57.7–63.6]	62.5 Gy [59.3–63.9]	< 0.01
	Mean	60.3 Gy [59.6–64.1]	68.7 Gy [66.2–71.7]	69.8 Gy [67.7–70.7]	0.05

Figure 3. The dose distribution in patient 3. BTV_per in dark green, BTV_met in purple, and PTV in blue. The 70 Gy isoshade is in red, and the 60 Gy isoshade is in green. Panel A shows an axial image where BTV_per is boosted, while BTV_met is boosted in the panel B.

Figure 4. Cohort-based mean dose volume histograms from the two boost regimes, either were BTV_met (A) or BTV_per (B) is boosted. PTV in black, BTV used for boosting in red, and corresponding non-boost BTV in green. The dotted lines indicate one standard deviation.