Ultra-high field ¹H magnetic resonance imaging approaches for acute hypoxia

Figures & data

Figure 1. BOLD MRI parametric maps of T₂* mean and SD for a control tumour.

Figure 2. DCE-MRI parametric maps for the same control tumour as shown in Figure 1. Initial maps and difference maps for the two DCE-MRI scans are shown.

Table I. BOLD MRI parameter values.

	T2* mean [ms]	T2* SD [μs]
Saline	7.50 ± 1.48	248 ± 33.8
Nicotinamide	8.74 ± 1.30	253 ± 26.6

Tumour median values of the T₂* mean and SD for the BOLD MRI time interval. Parameter values are shown as mean± SE of individual tumour medians. The data showed no statistically significant differences between the treatment groups.

Table II. DCE-MRI parameter values.

A	IAUC [mM*s]	K^trans [μs^−1]	ve [%]	vp [‰]
Saline	3.90 ± 0.804	545 ± 132	3.59 ± 0.409	1.19 ± 0.653
Nicotinamide	4.53 ± 0.327	342 ± 74.9	3.26 ± 0.256	8.71 ± 0.510*
B	IAUC [mM*s]	K^trans [μs^−1]	ve [%]	vp [‰]
Saline	4.43 ± 0.509	594 ± 121	3.69 ± 0.323	1.20 ± 0.360
Nicotinamide	4.77 ± 0.452	514 ± 160	3.08 ± 0.380	5.23 ± 0.634*
C	|ΔIAUC| [mM*s]	|ΔK^trans| [μs^−1]	|Δve| [‰]	|Δvp| [‰]
Saline	1.01 ± 0.540	161 ± 29.6	6.82 ± 0.906	1.72 ± 0.317
Nicotinamide	0.680 ± 0.0440	165 ± 61.2	6.44 ± 0.611	3.06 ± 0.401*

Parameter values are shown as mean± SE of individual tumour medians. A. Initial DCE-MRI values. B. DCE-MRI values for the second DCE-MRI scan. C. Absolute difference values between the two DCE-MRI scans. An asterisk (*) indicates for the nicotinamide group a statistically significant difference from the saline group.