Local control in non-metastatic medulloblastoma

Figures & data

Table I. Patient, tumor, and treatment characteristics.

Characteristic	Value
Median follow-up (range)	15.7 (range 0.3–44.4) years
Median age at diagnosis (range)	7.3 (range 1.2–18.5) years
Male	36 (72%)
Black	5 (10%)
Resection
Gross total resection	19 (38%)
Near total resection	9 (18%)
Subtotal resection	22 (44%)
Classic or unknown histology	46 (92%)
Chemotherapy
Preradiotherapy only	2 (4%)
Preradiotherapy + concurrent	1 (2%)
Preradiotherapy + maintenance	2 (4%)
Concurrent + maintenance	10 (20%)
Maintenance alone	3 (6%)
None	32 (64%)

Table II. Treatment data.

Treatment parameter	Value
Median radiotherapy dose (range)	54.3 Gy (range 42.4–64.8)
Median initial craniospinal irradiation dose (range)	28.8 Gy (range 21.8–38.4)
Median posterior fossa boost	25 Gy (range 14.1–38.4)
Median interval between surgery and start of radiotherapy	19 days (range 5–160 days)
Median duration of radiotherapy treatment	45 days (range 30–65 days)

Figure 1. Kaplan-Meier estimate of local control rate.

Figure 2. Kaplan-Meier estimate of local control stratified by patients who did and did not receive chemotherapy.

Figure 3. Kaplan-Meier estimate of local control rates stratified by treatment duration.

Table III. Patterns of progression.

Recurrence site	No. of patients	Time to relapse (months)
In-field posterior fossa only	4	2.8, 6.77, 21.7, 65
In-field and distant (neuro-axis)	2	28.8, 101.3
In-field and distant (non-neuroaxis)	1	14.4
Bone only	3	13.3, 24.8, 33.77
Distant (neuro-axis) only	5	4.4, 10.2, 11.7, 39.7,47.4