LRIG and cancer prognosis

Figures & data

Figure 1. Over- and under-expression of LRIG genes in human cancers compared with their normal tissue counterparts. Altered expression is indicated only when two or more studies in the Oncomine database showed over- or under-expression for their respective cancer type. Red indicates over-expression and green indicates under-expression in tumors versus normal tissue. Colorectal cancer showed both over- and under-expression of LRIG1. AML, acute myeloid leukemia; NSCLC, non-small cell lung cancer; SCC, squamous cell carcinoma; T-ALL, T-cell acute lymphoblastic leukemia.

Table I. Correlation between LRIG1 gene copy number status, LRIG1 mRNA expression, or LRIG protein expression and patient survival in various cancer types.

	LRIG1 gene copy number	LRIG1 RNA	LRIG1 protein	LRIG2 protein	LRIG3 protein
Bladder		Good^63
Breast	Good^2	Good^1,2,13
Cervical SCC			Good^3	Poor^4
Cervical adeno			Good^5		Good^5
Oligodendroglioma				Poor^10
Glioblastoma/astrocytoma		Good^63		Good^9	Good^9
HNSCC	Good^7		Good^8
NSCLC, SCC		Good^63,a	Good^a
NSCLC, adeno		Good^a	Good^a
Prostate			Good or Poor^11
Cutaneous SCC			Good^12
Malignant melanoma		Good^63

Adeno, adenocarcinoma; HNSCC, head-and-neck squamous cell carcinoma; NSCLC, non-small cell lung cancer; SCC, squamous cell carcinoma.

^aKvarnbrink et al., unpublished observations.