Peer support and additional information in group medical consultations (GMCs) for BRCA1/2 mutation carriers: A randomized controlled trial

Figures & data

Figure 1. CONSORT flowchart.

Table I. Carrier and treatment characteristics.

	Intervention group (n = 63)	Control group (n = 59)
	Mean± sd	Mean± sd
Age	42.24 ± 10.03	42.25 ± 10.00
Time since BRCA test result (yrs)	3.10 ± 3.97	3.76 ± 4.02
	N (%)	N (%)
BRCA1	36 (57)	31 (53)
BRCA2	27 (43)	28 (48)
Personal history of breast cancer	6 (10)	4 (7)
RRSO	31 (49)	32 (54)
Education level
Lower	3 (5)	3 (5)
Middle	37 (59)	29 (49)
Higher	23 (37)	27 (46)
Employment
Student	3 (5)	0
Paid work	48 (76)	42 (71)
Volunteer/home management	11 (17.4)	16 (27)
Retired	1 (2)	1 (2)
Marital status
Married	42 (67%)	37 (63%)
Cohabiting	14 (22%)	13 (22%)
Widowed	2 (3%)	1 (2%)
Unmarried	5 (8%)	7 (12%)
Divorced	0	1 (2%)

Table II. ANCOVA analysis on mean scores of primary and secondary outcomes in intervention and control group at T1 and T2 controlled for baseline scores (T0).

	T0 (mean± SD)	T1 (mean± SD)	Adj. mean difference (I-C) (95% CI)	F-stat	p-Value	T2 (mean± SD)	Adj. mean difference (I-C) (95% CI)	F-stat	p-Value
Distress			−0.098 (−6.0–5.8)	0.001	0.974		−5.415 (−13.2–2.4)	1.885	0.172
GMC	117.70 ± 32.36	112.45 ± 31.38				112.06 ± 34.27
Individual	114.83 ± 27.22	110.22 ± 26.76				114.87 ± 33.71
Empowerment			2.011 (−1.7–5.8)	1.129	0.290		0.123 (−4.0–4.2)	0.004	0.953
GMC	153.90 ± 22.50	156.95 ± 22.86				155.38 ± 24.29
Individual	155.68 ± 15.86	156.59 ± 19.83				157.00 ± 19.21
Cancer worry			−0.571 (−1.4–0.3)	2.001	0.160		−0.472 (−1.3–0.4)	1.257	0.264
GMC	14.02 ± 3.68	13.08 ± 3.95				12.84 ± 3.66
Individual	13.42 ± 3.87	13.17 ± 3.45				12.88 ± 3.31
Global Health status (EORTC-QLQ C30)			2.891 (−0.8–6.5)	2.463	0.119		4.299 (−0.6–9.2)	2.971	0.087
GMC	76.32 ± 15.57	80.56 ± 13.30				79.23 ± 15.76
Individual	82.34 ± 15.40	81.50 ± 14.85				78.95 ± 19.16
EORTC-BR23 subscales:
Body image			.107 (−3.3–3.5)	0.004	0.951		0.556 (−3.039–4.151)	0.094	0.760
GMC	88.36 ± 17.49	89.95 ± 17.21				90.61 ± 14.00
Individual	92.51 ± 13.01	92.80 ± 11.10				92.51 ± 13.55
Sexual functioning			−0.607 (−6.0–4.8)	0.050	0.824		5.292 (0.0–10.5)	3.987	0.048
GMC	32.54 ± 24.03	31.75 ± 24.08				33.86 ± 22.99
Individual	33.05 ± 21.51	32.47 ± 21.72				29.02 ± 18.09
Sexual enjoyment			3.916 (−4.3–12.1)	0.905	0.344		2.709 (−5.2–10.6)	0.462	0.499
GMC (n = 45)	65.93 ± 20.71	66.67 ± 22.65				61.90 ± 21.55
Individual (n = 44)	56.06 ± 26.68	55.83 ± 24.33				55.56 ± 23.36
Future perspective			−4.681 (−11.6–2.3)	1.776	0.185		3.864 (−3.7–11.4)	1.028	0.313
GMC	70.90 ± 26.43	73.55 ± 25.51				77.78 ± 26.77
Individual	67.82 ± 25.72	77.01 ± 20.90				71.84 ± 27.07

Figure 2. Themes discussed during GMCs and individual visits according to carriers, professionals and the observer.