Figures & data
Figure 1. Dose differences overlaid on a sagittal and axial CT slice (slice positions are indicated by white lines) between pure IMXT plan and mixed modality treatment plan (left column) as well as between pure IMXT treatment and pure IMPT treatment (right column) for two exemplary patients with primary tumor site in the oropharynx (upper row) and the hypopharynx (lower row). The elective target volume is depicted in dark red and the gross tumor volume (GTV) in blue. Dose differences are small in the sequential boost volume consisting of GTV and involved lymph nodes (not depicted), increasing in the part of the elective volume in which no sequential boost is applied (right neck in patient A, left neck in patient B) and largest in the normal tissue surrounding the elective volume.
Figure 2. Differences in NTCP between pure IMXT and pure IMPT (∆NTCPIMXT-IMPT, dark blue) and between pure IMXT and mixed modality treatment (∆NTCPIMXT-Mix, light blue) for individual patients sorted according to the ∆NTCPIMXT-IMPT values for three different toxicities. The gray dotted line indicates 10% difference used as possible selection criterion in the model-based approach.
Table I. Number of patients with ∆NTCP in the specified ranges.
Figure 3. Number of toxicities per patient for which NTCP was reduced by (a) more than 10% and (b) more than 5% compared to the pure IMXT technique. In total, seven toxicities were evaluated.
