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Original Article

A limited sampling strategy for estimation of the area under the curve (0 to 8 hours) of mycophenolic acid administered three times daily to liver transplant recipients

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Pages 47-51 | Received 11 Aug 2010, Accepted 09 Sep 2010, Published online: 01 Nov 2010

Figures & data

Figure 1. Correlation and regression between the trapezoidal mycophenolic acid (MPA) AUC(0–2h) and trapezoidal extrapolated MPA AUC(0–8h) in liver transplant recipients treated three times daily with mycophenolate mofetil (MMF) in monotherapy (Δ), or co-medicated with cyclosporin (•) or tacrolimus (○). The dashed lines correspond to the tentative therapeutic ranges for MPA AUC(0–2h) and AUC(0–8h).

Figure 1. Correlation and regression between the trapezoidal mycophenolic acid (MPA) AUC(0–2h) and trapezoidal extrapolated MPA AUC(0–8h) in liver transplant recipients treated three times daily with mycophenolate mofetil (MMF) in monotherapy (Δ), or co-medicated with cyclosporin (•) or tacrolimus (○). The dashed lines correspond to the tentative therapeutic ranges for MPA AUC(0–2h) and AUC(0–8h).

Table I. Correlation coefficients of the blood count of total, polymorphonuclear (PMN), and mononuclear (MN) leukocytes, and platelets with mycophenolic acid levels and AUC(0–2h) and AUC(0–8h) (n = 22).