Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats

Figures & data

Table I. Base-line values of body weight, mean arterial blood pressure (MAP), renal blood flow (RBF), renal vascular resistance (RVR), and heart rate (HR) in CT, DNX, L, DNX-L, CV, DNX-CV, LCV, and DNX-LCV. All data are expressed as mean ± SEM.

Treatment	n	Body weight (g)	MAP (mmHg)	RBF (mL min^-1 kg^-1)	RVR (mmHg min kg mL^-1)	HR (bpm)
CT	6	277 ± 8	110 ± 3	9.0 ± 1.0	13.4 ± 2.1	285 ± 12
DNX	6	281 ± 10	109 ± 7	10.1 ± 2.6	11.4 ± 2.2	312 ± 17
L	6	270 ± 7	110 ± 10	8.6 ± 3.1	8.9 ± 0.1	301 ± 13
DNX-L	6	278 ± 8	109 ± 9	11.8 ± 1.5	14.3 ± 4.1	299 ± 14
CV	6	288 ± 9	111 ± 4	11.6 ± 4.9	11.6 ± 4.6	258 ± 19
DNX-CV	6	290 ± 9	108 ± 8	9.8 ± 3.2	10.9 ± 3.1	300 ± 20
LCV	6	272 ± 5	115 ± 6	10.6 ± 2.5	11.4 ± 2.1	258 ± 19
DNX-LCV	6	284 ± 8	118 ± 12	11.2 ± 1.2	11.2 ± 0.7	237 ± 11

bpm = beats per minute.

Figure 1. Time course of the renal vasoconstrictor response to Ang II. MAP changes (top) and RBF response (bottom) following the administration of a bolus injection (20 ng) into the renal artery. The delay of about 30 s at the beginning of the response is due to the travel time in the cannula before reaching the renal vasculature. Stippled lines denote ± SEM, n = 5 rats.

Figure 2. Renal vasoconstrictor responses to graded doses of NA in CT, DNX, L, DNX-L, CV, DNX-CV, LCV, and DNX-LCV. *P < 0.05 compared to CT. ^# P < 0.05 compared to DNX. Data were analysed by two-way ANOVA followed by Bonferroni post-hoc test, n = 6 rats.

Figure 3. Renal vasoconstrictor responses to graded doses of ME in CT, DNX, L, DNX-L, CV, DNX-CV, LCV, and DNX-LCV. *P < 0.05 compared to CT. ^# P < 0.05 compared to DNX. Data were analysed by two-way ANOVA followed by Bonferroni post-hoc test, n = 6 rats.

Figure 4. Renal vasoconstrictor responses to graded doses of Ang II in CT, DNX, L, DNX-L, CV, DNX-CV, LCV, and DNX-LCV. *P < 0.05 compared to CT. ^# P < 0.05 compared to DNX. Data were analysed by two-way ANOVA followed by Bonferroni post-hoc test, n = 6 rats.