Urotensin II levels in patients with chronic kidney disease and kidney transplants

Figures & data

Table I. Characteristics of the participants.

	Group 1	Group 2	Group 3	P value
n	35/110	36/110	39/110	-
Age (years)	37.4 ± 13.8	36.8 ± 6.8	38.3 ± 5.6	NS
Sex (F/M) (n)	12/23	14/22	18/21	NS
Creatinine (RI 0.60–1.10 mg/dL)	1.10 ± 0.20	5.98 ± 1.52	0.75 ± 0.23	0.001^a, NS^b, 0.000^c
CCBs^d	24/35 (68.6%)	21/36 (58.3%)	0/39 (0.0%)	NS^a
ACE inhibitors or ARBs^d	10/35 (28.6%)	14/36 (38.9%)	0/39 (0.0%)	NS^a
UII (ng/mL)	0.66 (0.16–188)^e	0.48 (0.06–1.14)^e	0.59 (0.06–1.85)^e	0.017^f

^aComparing group 1 with group 2.

^bComparing group 1 with group 3.

^cComparing group 2 with group 3.

^dAlone or in combination with other antihypertensive drugs.

^eMedian (min–max).

^fKruskal–Wallis test.

RI = reference interval; NS = not significant; CCBs = calcium channel blockers; ACE = angiotensin-converting enzyme; ARBs = angiotensin receptor blockers; UII = plasma urotensin II level.

Table II. Comparison of log (UII × 1000) levels between males and females.

Groups	Log (UII × 1000) levels (total)^a	Gender	No. of cases	Log (UII × 1000) levels
				Mean ± SE
1	3.0035 ± 0.60478	Male	23	3.0686 ± 0.67444
		Female	12	2.8787 ± 0.44153
2	2.6403 ± 0.29595	Male	22	2.7468 ± 0.22989
		Female	14	2.4730 ± 0.31798
3	2.7400 ± 0.24080	Male	21	2.7607 ± 0.27365
		Female	18	2.7158 ± 0.20089

^aOne-way analysis of variance (ANOVA) test’s P value was 0.001 (see text).

UII = plasma urotensin II level (ng/mL); SE = standard error of the mean.

Figure 1. Comparison of log (UII × 1000) levels between the groups. EMM = estimated marginal means; UII = urotensin II (ng/mL).