Figures & data
Figure 1. The most prominent ligand-receptor interactions with superior affinity over other ligands, i.e. IGF-1 to the IGF-1R and hybrids with either IR-A or IR-B, IGF-2 binds with high affinity IGF-1R, IR-A, and heterodimers with this isoform, while insulin displays high affinity for the IR and splice variants IR-A and IR-B only.
Figure 2. The H3K27me3 target genes defined by Bracken et al. (Citation81) in embryonic fibroblasts are statistically associated to underexpressed genes in MM and MGUS using the data-mining platform Oncomine. A: The top 10% underexpressed genes in MM patients (compared to normal bone-marrow) show a strong connection to genes previously described as H3K27me3 targets in human embryonic fibroblasts. B: The H3K27me3 target genes were also overrepresented among genes underexpressed in MGUS patients, and (C) strongly associated with decreased expression in ISS stage III MM, compared to stage I and II. D: The PRC2 targets CIITA, GATA2, CDH6, CXCL12, and ICSBP/IRF8 are underexpressed in MM. From Kalushkova et al. (Citation10) with permission.
Figure 3. A: In a preclinical setting a few selected candidate target genes from the integrative genomic analysis were analyzed and found to be reactivated by chemical inhibitors in MM cell lines in vitro. B: Treatment with LBH589 significantly reduced tumor load in the 5T3MM mouse model, and also increased overall survival in this model (C). From Kalushkova et al. (Citation10) with permission.
