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Upsala Journal of Medical Sciences Volume 117, 2012 - Issue 2: Frontiers in tumor biology research - a tribute to Bengt Westermark
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REVIEW ARTICLE

PDGF and PDGF receptors in glioma

Inga NazarenkoDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden
,
Sanna-Maria HedeDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden;(currently) Uppsala University, Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, SE-751 85 Uppsala, Sweden
,
Xiaobing HeDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden
,
Anna HedrénDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden
,
James ThompsonDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden;Karolinska Healthcare Research Biobank (KHRBB), Clinical Pathology/Cytology, Karolinska University Hospital, SE-17176 Stockholm, Sweden
,
Mikael S. LindströmDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden
&
Monica NistérDepartment of Oncology-Pathology, Karolinska Institutet, CCK R8:04, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden;Karolinska Healthcare Research Biobank (KHRBB), Clinical Pathology/Cytology, Karolinska University Hospital, SE-17176 Stockholm, SwedenCorrespondence[email protected]
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Pages 99-112 | Received 24 Jan 2012, Accepted 06 Feb 2012, Published online: 17 Apr 2012

Figures & data

Figure 1. Receptor binding specificity of five dimeric PDGF ligands. *Ligand DD can activate αβ with lower specificity.

Figure 1. Receptor binding specificity of five dimeric PDGF ligands. *Ligand DD can activate αβ with lower specificity.

Figure 2. Three possible ways for a cancer stem cell (CSC) to arise: a neural stem cell (NCS) acquires a mutation; a progenitor cell (PC) acquires two or more mutations; or a fully differentiated cell (DC) undergoes several mutations that transform and drive it back to a stem-like state.

Figure 2. Three possible ways for a cancer stem cell (CSC) to arise: a neural stem cell (NCS) acquires a mutation; a progenitor cell (PC) acquires two or more mutations; or a fully differentiated cell (DC) undergoes several mutations that transform and drive it back to a stem-like state.
 

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