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Original Article

Sequential Organ Failure Assessment (SOFA) scores differ between genders in a sepsis cohort: Cause or effect?

, , , &
Pages 415-425 | Received 11 May 2012, Accepted 11 Jun 2012, Published online: 16 Jul 2012

Figures & data

Table I. Patient characteristics.

Table II. Treatment, fluids, and antibiotics.

Table III. Scoring and outcome.

Figure 1. Proportion of patients with SOFA organ sub-score ≥3 as a sign of organ failure (females and males) and proportion of patients with SOFA organ sub-score <3 (females and males). SOFA sub-scores: circ = circulatory; resp = respiratory; renal = renal; coag = coagulation; CNS = central nervous system; hep = liver function.

Figure 1. Proportion of patients with SOFA organ sub-score ≥3 as a sign of organ failure (females and males) and proportion of patients with SOFA organ sub-score <3 (females and males). SOFA sub-scores: circ = circulatory; resp = respiratory; renal = renal; coag = coagulation; CNS = central nervous system; hep = liver function.

Figure 2. Differences between genders in SOFA scores and CRP max in relation to hospital outcome. Panel A: SOFA score at admission (SOFA_0) was significantly higher in non-surviving than surviving women (P = 0.001), but not among surviving compared to non-surviving men. Panel B: SOFA score day 1 (SOFA_1) was significantly higher among hospital non-surviving compared to surviving women (P = 0.008), but in men SOFA_1 was significantly lower in non-surviving men compared to surviving men (P = 0.035). Panel C: SOFA_max was significantly higher among hospital non-survivors compared to survivors in both women (P = 0.001) and men (P = 0.017). Panel D: The interaction between gender and CRP as a risk factor for hospital mortality. CRP_max was significantly lower in surviving women than in non-surviving women (P = 0.035). Men displayed a different pattern with higher CRP in surviving men than non-surviving men, although the difference was not statistically significant (P = 0.081). (CRP = C-reactive protein. Data are presented as mean ± 95% confidence intervals).

Figure 2. Differences between genders in SOFA scores and CRP max in relation to hospital outcome. Panel A: SOFA score at admission (SOFA_0) was significantly higher in non-surviving than surviving women (P = 0.001), but not among surviving compared to non-surviving men. Panel B: SOFA score day 1 (SOFA_1) was significantly higher among hospital non-surviving compared to surviving women (P = 0.008), but in men SOFA_1 was significantly lower in non-surviving men compared to surviving men (P = 0.035). Panel C: SOFA_max was significantly higher among hospital non-survivors compared to survivors in both women (P = 0.001) and men (P = 0.017). Panel D: The interaction between gender and CRP as a risk factor for hospital mortality. CRP_max was significantly lower in surviving women than in non-surviving women (P = 0.035). Men displayed a different pattern with higher CRP in surviving men than non-surviving men, although the difference was not statistically significant (P = 0.081). (CRP = C-reactive protein. Data are presented as mean ± 95% confidence intervals).

Table IV. Analysis of risk factors for hospital death.