Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: A double-blind, randomized and placebo-controlled study

Figures & data

Table I. BDNF plasma concentrations.

	Group A (n = 19)	Group B (n = 18)
T1	196.1 ± 36.7 (141.4–268.6)	173.8 ± 40.0 (113.7–274.6)
T2	120.9 ± 17.6 (92.5–159.5)	167.3 ± 36.8^a (109.4–264.9)
T3	167.3 ± 19.9 (113.6–192.5)	165.3 ± 34.9 (119.2–255.6)
T4	154.9 ± 28.6 (107.8–194.5)	164.8 ± 29.4 (114.2–254.4)
T5	126.8 ± 28.2 (90.4–190.4)	176.0 ± 26.9^a (149.4–260.4)

T1 = baseline; T2 = 15 minutes after intubation before the operation started; T3 = skin closure; T4 = 10 minutes after extubation in the PACU; T5 = 24 hours after the operation. ^a P < 0.05 versus control.

Table II. Changes in patients' heart rates.

	Group A	Group B
Baseline	78 ± 6.6	78 ± 7.0
Study drug injection	78 ± 6.8	63 ± 4.2^a
Anesthesia induction	65 ± 4.4	53 ± 2.7^a
Intubation	93 ± 7.0	86 ± 9.1^a

^a P < 0.05 versus control.

Table III. BIS value variation during surgery.

	Group A	Group B
Baseline	98.6 ± 0.5	98.2 ± 0.6
Anesthesia induction	40.3 ± 2.3	39.1 ± 3.5
Intubation	64.5 ± 4.3	51.4 ± 2.8^a
Skin cut	54.3 ± 4.9	46.8 ± 2.5^a
Skin closure	59.6 ± 4.4	59.5 ± 3.2

^a P < 0.05 versus control.

Table IV. Duration of surgery, amount of bleeding and volume therapy, and the dose of induction anesthetics.

	Group A	Group B
Duration of surgery (min)	109.3 ± 7.1	104.6 ± 10.6
Bleeding (mL)	102.1 ± 10.3	103.9 ± 9.2
Volume therapy (mL)	1442.1 ± 161.0	1436.1 ± 173.9
Propofol for induction (mg)	92.1 ± 15.1	36.9 ± 6.0^a
Sulfentanil for induction (mg)	36.8 ± 5.06	20.4 ± 5.1^a

^a P < 0.05 versus control.