Predictors of liver failure in primary biliary cirrhosis

Figures & data

Figure 1. Patient enrollment.

Figure 2. Cumulative incidence of liver failure in patients with primary biliary cirrhosis during follow-up.

Table I. Comparison of baseline characteristics at entry between patients with and without liver failure.

Parameters	Patients not developing liver failure (n = 360)	Patients who developed liver failure (n = 38)	p value
Sex (male/female)	75/285	6/32	0.463
Age (years)	55 (15)	60 (11)	0.056
ALT (U/L)	52 (58)	56 (70)	0.899
AST (U/L)	70 (61)	88 (85)	0.094
ALT (U/L)	169 (118)	176 (112)	0.736
GGT (U/L)	217 (288)	238 (278)	0.552
Total bilirubin (μmol/L)	23.2 (44.5)	43.7 (46.3)	0.013
Albumin (g/L)	36 (7)	35 (6)	0.905
Total cholesterol (mmol/L)	4.52 (2.91)	3.09 (2.11)	0.008
Total bile acid (μmol/L)	46.0 (91.0)	92.5 (97.0)	< 0.001
IgA (g/L)	2.81 (1.67)	3.81 (3.76)	0.070
IgM (g/L)	2.81 (3.23)	2.01 (1.65)	0.099
IgG (g/L)	15.69 (8.49)	17.92 (8.94)	0.224
AMA (+/–)	352/8	37/1	0.599
ANA (+/–)	157/203	25/13	0.009

Continuous data were expressed as median (interquartile range).

Table II. Predictors of liver failure in primary biliary cirrhosis.

Parameters	Odds ratio (95% CI)	Standardized odds ratio (95% CI)	p value
Total cholesterol (mmol/L)	0.552 (0.394–0.774)	0.313 (0.162–0.606)	< 0.001
Total bile acid (μmol/L)	1.006 (1.002–1.010)	1.397 (1.130–1.727)	0.002
ANA (+ versus –)	5.518 (1.155–26.376)	5.518 (1.155–26.376)	0.032