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Hemoglobin
international journal for hemoglobin research
Volume 34, 2010 - Issue 5
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Short Communications

Further Studies on Hb Canebière [β12(G4)Asn→His], a Low Affinity Hemoglobin Variant

Ulf Froelund Department of Hematology, Herlev University Hospital, Herlev, Denmark
,
Erik Sandbakken Department of Medicine Y, Gentofte University Hospital, Hellerup, Denmark
,
Pal Szecsi Department of Clinical Biochemistry, Gentofte University Hospital, Hellerup, Denmark
&
Henrik Birgens Department of Hematology, Herlev University Hospital, Herlev, DenmarkCorrespondence[email protected]
Pages 495-499 | Received 24 Mar 2010, Accepted 03 May 2010, Published online: 20 Sep 2010
 
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Abstract

A case of Hb Canebière [β102(G4)Asn→His] was diagnosed in an otherwise healthy 21-year-old Danish woman. The clinical consequences were minor, since her only symptom consisted of transient cyanosis in lips and fingers when exposed to cold environments. Whole blood p50 was 59.9 mmHg. The Hb Canebière variant could not be separated from Hb A by high performance liquid chromatography (HPLC) and isoelectric focusing (IEF), and it was thus missed by routine hemoglobin (Hb) fractionation techniques.

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