Genetic variants in MTNR1B affecting insulin secretion

Figures & data

Figure 1. Genomic region of human chromosome 11 harbouring the MTNR1B gene locus and linkage disequilibrium (LD) data of representative single nucleotide polymorphisms (SNPs) within this region (HapMap data). The MTNR1B gene consists of 2 exons and spans 13,160 bases from nucleotide 92,342,437 to nucleotide 92,355,596. The locations of the genotyped representative SNPs are indicated by arrows. The HapMap minor allele frequencies (MAF) are given below the SNP numbers. The Haploview LD colour scheme ‘r-squared’ was chosen to visualize LD data. Within the diamonds, the r² values are given. SNP rs8192552 (G24E) is not covered by the HapMap data and was added, therefore, on the right side of the diamonds. No linkage data are available for this SNP.

Table I. Associations of single nucleotide polymorphisms within or in proximity to the MTNR1B gene locus with prediabetes phenotypes and risk of type 2 diabetes.

Single nucleotide polymorphism	Risk allele (frequency)	Metabolic phenotype of risk allele carriers	References
rs1387153	T (0.30)	Impaired fasting plasma glucose, increased type 2 diabetes risk (odds ratio = 1.15)	(27)
rs2166706	C (0.45)	Impaired fasting plasma glucose, increased type 2 diabetes risk (odds ratio = 1.21)	(32)
rs10830962	G (0.40)	Impaired fasting plasma glucose, reduced β-cell function	(25)
rs4753426	C (0.50)	Impaired fasting plasma glucose, reduced β-cell function	(25)
rs10830963	G (0.30)	Impaired fasting glucose, reduced (β-cell function, increased type 2 diabetes risk (mean odds ratio =1.15; range 1.09–1.23)	(16,25,26,28–31,33,36–39)
rs3781638	A (0.55)	Impaired fasting glucose, reduced β-cell function, diminished insulin sensitivity	(25)
rs8192552	G (0.90)	Impaired fasting glucose, decreased body mass	(35)

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Andersson EA, Holst B, Sparso T, Grarup N, Banasik K, Holmkvist J, . The MTNR1B G24E variant associates with BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes. 2010;59: 1539–48.

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