Golgi pH, its regulation and roles in human disease

Figures & data

Figure 1. Schematic representation of the compartmentalized secretory (biosynthetic) and endocytic (degradative) pathways and their convergence at the level of the Golgi apparatus (modified from (146)). Note the different steady-state pH values of each organelle. ERGIC is a pleiomorphic membrane structure between the ER and the Golgi, where proteins are arrested at 15°C (26).

Figure 2. The multisubunit structureof the V-ATPase (modified from (146)). For further details, see text.

Figure 3. An integrated view of Golgi pH regulation with the main ion transport systems involved.

Rivinoja A. Golgi pH and glycosylation [thesis]. Acta Universitatis Ouluensis. A scientiae rerum naturalium 535. Oulu: University of Oulu; 2009.

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Saraste J, Kuismanen E. Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface. Cell. 1984;38:535–49.

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