Figures & data
Figure 1. MiRNome analysis for circulating microRNAs in migraine. Schematic representation of circulating microRNAs as modulated by migraine. The x-axis indicates fold change in expression level on a log10 scale as compared to control subjects.
Figure 2. Validation of circulating microRNAs expression on individual plasma samples by qRT-PCR. Data are shown as fold change from the control group. Significance levels were assessed by Mann–Whitney U test. * q < 0.05; ** q < 0.01; *** q < 0.001 (probability values corrected for multiple comparison by the Benjamini–Hochberg FDR method; n = 13 for control subjects, n = 15 for migraine patients).
Figure 3. Receiver-operating characteristic (ROC) curve derived from the logistic regression model developed with circulating let-7b, miR-22, miR-27b, and miR-181a as predictors. AUC = area under curve.
Figure 4. Expression of microRNAs in peripheral blood mononuclear cells (PBMCs) assessed by qRT-PCR. Data are shown as fold change from the control group. Significance levels were assessed by Mann–Whitney U test. *P < 0.05; ** P < 0.01; *** P < 0.001 (n = 13 for control subjects, n = 15 for migraine patients).
