Impaired aortic elastic properties in patients with adult-onset hypogonadism

Figures & data

Table I. Baseline clinical and laboratory characteristics of the hypogonadal and control groups.

	Hypogonad patients (n = 22)	Eugonad subjects (n = 25)	P-value
Age, years	35.2 ± 9.5	34.5 ± 8.2	0.45
Gender, male	22 (100%)	25 (100%)	1.0
BMI, kg/m^2	24.5 ± 4.2	24.3 ± 3.9	0.70
Smoker	2 (9%)	3 (8%)	0.85
Pulse, beats/min	74.2 ± 10.6	71.8 ± 9.8	0.09
SBP, mmHg	112.8 ± 14.2	109.5 ± 13.6	0.48
DBP, mmHg	63.6 ± 9.6	61.4 ± 8.8	0.65
Pulse pressure, mmHg	49.7 ± 8.7	48.8 ± 8.2	0.82
FPG, mg/dl	87.3 ± 12.5	78.4 ± 14.4	0.52
Total cholesterol, mg/dl	195.5 ± 36.2	194.6 ± 35.8	0.18
HDL-cholesterol, mg/dl	38.5 ± 9.6	39.1 ± 8.2	0.44
LDL-cholesterol, mg/dl	125.2 ± 35.6	123.8 ± 37.2	0.58
Triglyceride, mg/dl	144.8 ± 78.2	142.5 ± 75.5	0.62
Total testosterone, ng/dl	242.5 ± 32.2	455.5 ± 48.7	< 0.001
Free testosterone, pg/ml	4.21 ± 2.1	10.4 ± 4.3	< 0.001
FSH, mIU/ml	1.22 ± 1.0	5.1 ± 2.8	< 0.001
LH, mIU/ml	0.85 ± 0.57	4.1 ± 2.5	< 0.001

BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FSH, follicle-stimulating hormone; LH, luteinizing hormone.

Figure 1. Correlation between the aortic distensibility/strain and serum total testosterone level.

Figure 2. Correlation between the β index and serum total testosterone level.

Table II. Aortic elastic properties in the hypogonadal and eugonadal control men.

	Hypogonad patients (n = 22)	Eugonad subjects (n = 25)	P-value
Systolic aortic diameter, mm	32.1 ± 4.4	33.3 ± 4.2	0.066
Diastolic aortic diameter, mm	29.8 ± 3.5	28.7 ± 3.9	0.085
Pulsatile diameter change, mm	3.1 ± 1.1	4.9 ± 1.4	< 0.001
Aortic strain, %	12.4 ± 3.9	16.6 ± 4.2	< 0.001
Aortic distensibility, 10^−6 cm^2/dyn	5.4 ± 1.9	6.9 ± 2.3	< 0.001
Aortic stiffness index (β)	3.1 ± 1.1	2.3 ± 0.9	0.002