Does the 9p region affect arterial stiffness? Results from a cohort of hypertensive individuals

Figures & data

Table I. Demographic characteristics of the cohort overall and by gender.

Variable	All	Males	Females	p-value
(%)	821	464 (57)	357 (43)
Age, years	53.92 (13.72)	52.98 (13.46)	55.14 (13.98)	0.0248
BMI, kg/m^2	26.76 (4.19)	27.38 (3.63)	25.94 (4.70)	< 0.0001
SBP, mm Hg	142.40 (18.34)	142.93 (18.07)	141.7 (18.68)	0.345
DBP, mm Hg	86.78 (10.55)	87.64 (10.68)	85.65 (10.28)	0.0077
CF ECG bpm	66.42 (10.74)	65.28 (10.93)	67.90 (10.32)	0.0006
Total cholesterol, mg/dL	197.03 (35.19)	192.43 (33.84)	202.98 (36.05)	< 0.0001
HDL cholesterol, mg/dL	53.46 (13.62)	48.97 (11.6)	59.31 (13.86)	< 0.0001
LDL cholesterol, mg/dL	118.72 (31.87)	117.16 (31.47)	120.74 (32.32)	0.1521
Triglycerides, mg/dL	121.66 (77.96)	129.51 (81.75)	111.39 (71.54)	0.0015
Glucose mg/dL	89.99 (23.27)	92.66 (25.99)	86.52 (18.63)	0.0004
Creatinine mg/dL	0.86 (0.22)	0.96 (0.21)	0.75 (0.16)	< 0.0001
LVMI g/m^2	111.52 (32.71)	119.91 (32.25)	100.58 (30.01)	< 0.0001

BMI, body mass index; SBP, systolic blood pressure; DBP, Diastolic Blood Pressure; CF ECG, cardiac frequency electrocardiogram; LVMI, left ventricular mass index.

Figure 1. Regional association plot for rs300622.

Figure 2. Regional association plot for rs2381640.

Table II. Allelic distribution of rs300622 and rs2381640.

SNP	Major allele	Minor (effect) allele	Major allele frequency	Minor allele frequency	Beta	SE	p-value
rs300622	A	C	0.87	0.13	0.017	0.006	0.003
rs2381640	C	T	0.70	0.30	0.013	0.004	0.003