Local application of tropicamide 0.5% reduces retinal capillary blood flow

Figures & data

Figure 1. Mean of retinal capillary blood flow before (OD-before; OS-before) and 30 min after tropicamide application to the right eye (OD-tropicamide; OS-control). OD, right eyes; OS, left eyes; significance **p < 0.01 (Wilcoxon test).

Table I. Mean ± standard deviation (SD) of retinal capillary blood flow (RCF) before and 30 min after tropicamide application to the right eye (tropicamide); left eye (control).

	RCF [AU], mean ± SD
	Tropicamide	Control	Differences [%] tropicamide/control, mean ± SD	p
Before application of tropicamide	320 ± 103	352 ± 84	− 6.81 ns ± 27.9	0.26
30 min. after application of tropicamide	217 ± 82	335 ± 131	− 29.8** ± 27.9	0.006
Differences [%] before/after tropicamide	− 31.9** ± 12.6	− 6.79 ns ± 20.1
n	13	13
p	0.001	0.25

n, number of the paired samples; significance: ns, p > 0.05 ns; **p < 0.01; *0.05 ≥ p ≥ 0.01 (Wilcoxon test).

Figure 2. Mean differences in percent of baseline of retinal capillary blood flow 30 min after tropicamide application to the right eye and retinal capillary blood flow before application. OD, right eyes with local tropicamide application; OS, left eyes without tropicamide; significance **p < 0.01 (Wilcoxon test).

Figure 3. Mean of retinal capillary blood flow (RCF) before, 1, 5, 10, 15, 20 and 30 min after tropicamide application to the right eye; N, number of paired samples; significance *0.05 ≥ p ≥ 0.01, comparison of RCF between the right eyes and the left eyes; #comparison between RCF in the time of the measurement after and before tropicamide application (Wilcoxon test).

Table II. Mean ± standard deviation (SD) of retinal capillary blood flow (RCF) before, 1, 5, 10, 15, 20 and 30 min after tropicamide to the right eye; OD/OS difference – difference between RCF of the right eyes (OD) and control left eyes (OS).

	Retinal capillary blood flow, mean ± SD
Time of measurement, [min]	OD tropicamide [AU]	OS control [AU]	OD/OS difference [AU]	OD/OS difference [%]	n	p
0	330 ± 100	343 ± 89	− 13 ± 28	− 6 ± 10	6	0.25
1	343 ± 80	344 ± 70	− 1 ± 34	− 0.2 ± 10	6	0.92
5	280 ± 56	371 ± 107	− 91 ± 97*	− 21 ± 19*	6	0.046
10	240 ± 43	346 ± 91	− 106 ± 63*	− 29 ± 11*	6	0.028
15	267 ± 18	371 ± 112	− 104 ± 95*	− 23 ± 19*	6	0.046
20	233 ± 62	345 ± 105	− 111 ± 104*	− 29 ± 23*	6	0.046
30	276 ± 54	340 ± 116	− 63 ± 121	− 12 ± 33	6	0.173

n, number of paired samples; significance: n, p > 0.05; **p < 0.01; *0.05 ≥ p ≥ 0.01 (Wilcoxon test).