Effects of Everolimus on Cytokines, Oxidative Stress, and Renal Histology in Ischemia-Reperfusion Injury of the Kidney

Figures & data

Table 1  Biochemical results in our study

		Ischemia-reperfusion group		IR/everolimus group
	Control group	2 hours	24 hours	2 hours	24 hours
BUN (mg/dL)	25.9 (± 2.96)	40.4 (± 7.9)	21.3 (± 2.1)	43.9 (± 3.4)	37.6 (± 2.7)
Cre (mg/dL)	0.3 (± 0.07)	0.54 (± 0.14)	0.4 (± 0.1)	0.51 (± 0.11)	0.47 (± 0.22)
TNF-α (pg/mL)	33.4 (± 39.5)	66.5 (± 62.8)	14.8 (± 5.1)	13.1 (± 1.6)	17.7 (± 9.2)
IL-6 (pg/mL)	221.9 (± 78.6)	350.8 (± 184.9)	168.4 (± 62.8)	520.7 (± 230)	382.9 (± 246.7)
MPO (U/g)	1.98 (±0.6)	2.5 (± 0.5)	2.4 (± 0.4)	2.1 (± 0.2)	1.8 (± 0.4)
MDA (nmol/g)	181.7 (± 50.9)	214.1 (± 42.7)	260.6 (± 14.5)	153.6 (± 56.3)	156.2 (± 48.5)
SOD (U/g)	9.8 (± 1.3)	7.5 (± 1.6)	8.7 (± 1.5)	7 (± 1.6)†	7.8 (± 1.3)

*p > 0.05 vs. control.

†p < 0.05 vs. control.

‡p > 0.05 vs. IR group (for same hours).

§p <0.05 vs. IR group (for same hours).

Figure 1.  Normal histological findings in control group.

Figure 2.  Tubular dilatation and intratubular cast formation in IR and IR/eve groups.