The Effect of Heavy Muscle Activity on Renal Cytoresistance in Rats

Figures & data

Table 1  Studied parameters in rats from sedentary control and five-day exhausted groups

Groups	Sedentary control	Heavy muscle activity
MAP (mmHg)	91.20 ± 1.83	86.75 ± 3.69
GFR (mL/dk)	0.572 ± 2.1	0.659 ± 0.11
RBF (mL/dk)	5.45 ± 1.03	7.61 ± 0.99
Urinary glucose (mg/mL)	0.003 ± 0.0027	0.293 ± 0.070
Urinary protein (mg/dL)	0.054 ± 0.072	0.486 ± 0.071^†
FENa^+	0.151 ± 0.04	0.111 ± 0.04
FEK^+	52.52 ± 9.32	57.16 ± 13.37
Serum total  cholesterol (mg/mL)	0.97 ± 0.04	1.17 ± 0.11
HDL cholesterol (mg/mL)	0.28 ± 0.026	0.30 ± 0.045
LDL cholesterol (mg/mL)	0.671 ± 0.034	0.869 ± 0.09

Statistically differences from sedentary control; *p < 0.01, ^†p < 0.001.

Figure 1.  CS activity for soleus muscle and blood lactate levels in the sedentary control and in five-day exhausted animals (difference from sedentary control; *p < 0.001).

Figure 2.  Total cholesterol (TC), free cholesterol (FC), and cholesterol ester (CE) levels in proximal tubules isolated from sedentary control and five-day exhausted animals (differences from sedentary controls; *p < 0.05, **p < 0.01).

Figure 3.  LDH release from proximal tubules isolated from control and five-day exhausted rats. LDH release was determined in the basal and ATP-depleted/Ca⁺² overloaded conditions (7.5 μM Antimycin A, 20mM 2-deoxyglucose and 10 μM A23187) and expressed as percentage of total LDH (differences from individual basal conditions; *p < 0.001).